A unique malignant cell type per patient tumor encoded in each cancer cell transcriptome. [PDF]
Saurty-Seerunghen MS +6 more
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Measurement Equivalence of Diabetes Self-Management, Distress, and Quality-of-Life Measures in Adults with Type 2 Diabetes in Vietnam. [PDF]
Nguyen TT +7 more
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
How Grouping Data over Time Can Hide Signs of Stock Status: A Case Study Using LBSPR on Frigate Tuna (<i>Auxis thazard</i>, Lacépède, 1800) in the Northeast Atlantic Ocean. [PDF]
Bayon MS +5 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Interrogating cognitive and neural group variation in childhood: Examples in adolescent brain cognitive development and Oregon attention-deficit/hyperactivity disorder-1000 cohorts. [PDF]
Karalunas SL +10 more
europepmc +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Synergistic Multi-Model Fusion for Efficient-Accurate Multi-Defect Detection in Power Lines. [PDF]
Xi L, Shen T, Zhao G, Wang N, Li Z.
europepmc +1 more source
Group representations without groups
Gabriel, P., Riedtmann, Ch.
openaire +2 more sources

