Results 271 to 280 of about 1,468,899 (328)

Structure-Aware Multi-Animal Pose Estimation for Space Model Organism Behavior Analysis. [PDF]

Animals (Basel)
Liu K, Li S, Lv Y, Yang R, Li X.
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The effect of Massa Medicata Fermentata on the cytokine secretion of colonic mucosa and visceral sensitivity in rats with IBS-D. [PDF]

Front Cell Infect Microbiol
Zhuang Z, Lv B, Chen Y, Chen J.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Spatial Guidance Overrides Dynamic Saliency in VR: An Eye-Tracking Study on Gestalt Grouping Mechanisms and Visual Attention Patterns. [PDF]

J Eye Mov Res
Zou Q, Zheng W, Jiang X, Li D.
europepmc   +1 more source

Wearing Regulation Soft-Padded Headgear Does Not Reduce the Risk of Head Injuries in Professional Men's Rugby Players: An Observational Cohort Study. [PDF]

Eur J Sport Sci
Brown J, Douglas M, Hester B, Mohan M, Hendricks S, Wiseman B, Boshoff M, Phillips S, Bromfield M, Howard A, Starling L, Jones B, Tucker R.   +12 more
europepmc   +1 more source

Early Adoption of Services for Health-Related Social Needs in Medicare.

JAMA Health Forum
Billig JI, Joo JH, Cardin JR, Dang MD, Lin CC, Stimpson JP, Liao JM.   +6 more
europepmc   +1 more source

Optimization of diagnosis-related groups for patients with acute appendicitis using a machine learning model. [PDF]

Front Public Health
Gu X, Li N, Wang H.
europepmc   +1 more source

Participation, Cooperation and Conflict in UN Climate Negotiations. [PDF]

Sci Data
Castro P, Kristof V, Kammerer M, Cogne T.   +3 more
europepmc   +1 more source

Sleep duration promotes resistance and resilience to tau in older women at risk for Alzheimer's disease. [PDF]

Alzheimers Dement
Stiver J, Wang X, Lui KK, Dratva MA, Lifset ET, Heyworth NC, Rivera CS, Malhotra A, Thomas ML, Sundermann EE, Banks SJ.   +10 more
europepmc   +1 more source