Results 221 to 230 of about 32,521 (269)

Rethinking therapsid phylogeny through Bayesian and cladistic approaches. [PDF]

Sci Rep
Duhamel A, Wynd B, Wright AM, Moopen A, Benoit J, Rubidge B.   +5 more
europepmc   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Genome-wide analysis of AP2/ERF gene family in Camellia oleifera and its potential roles in ethylene-induced fruit abscission. [PDF]

BMC Plant Biol
Yi J, Su Y, He J, Wang J, Wang H, Zhang Y.   +5 more
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Biodiversity resilience in a tropical rainforest. [PDF]

Nature
Metz T, Farwig N, Dormann CF, Schaefer HM, Guevara-Andino JE, Brehm G, Burneo S, Chao A, Chazdon RL, Colwell RK, Diniz UM, Donoso DA, Endara MJ, Erazo S, Escobar S, Falconí-López A, Feldhaar H, Villamarin MG, Grella N, Heer K, Heethoff M, Keller A, Landim AR, Leonhardt SD, Lopez ET, Marín-Armijos D, Müller J, Neira-Salamea K, Neuschulz EL, Pedersen KM, Rödel MO, Schleuning M, Schmitt T, Staab M, Tartara A, Tinoco BA, Tremlett CJ, Tschapka M, Unsicker S, Villa-Galaviz E, Blüthgen N.   +40 more
europepmc   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source

Microbiome signatures of mangroves and salt marsh halophyte rhizosphere soil sediments: a metagenomic approach. [PDF]

Sci Rep
Sujeeth NK, Dharani Bommi KB, Manojkumar S, Angayarkanni J, Gnanadesigan M.   +4 more
europepmc   +1 more source

Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression

Advanced Science, EarlyView.
The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren, Xiaogang Li, Hao Li, Zenghui Cao, Mengtian Hou, Chunlei Zhao, Nan Lou, Sasa Hu, Yanzhe Li, Qian Ma, Yaoyao Li, Yi Fan, Kunkun Zhao, Kai Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Haitao Liu, Xingli Ma, Xingxiang Wang, Dongmei Yin   +20 more
wiley   +1 more source

Systematic Characterization of <i>Cacopsylla chinensis</i> as a Potential Vector of <i>Erwinia amylovora</i> on Korla Fragrant Pear in Xinjiang, China. [PDF]

Insects
Yuan Y, He Z, Wang L, Liu X, Liu Z, Li Y, Liu H, Zhang W.   +7 more
europepmc   +1 more source

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective

Advanced Science, EarlyView.
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok, Jesús Valdés‐Hernández, Varinia Bernales, Alán Aspuru‐Guzik, Alex Zhavoronkov   +4 more
wiley   +1 more source