Results 221 to 230 of about 173,617,415 (290)

A Perspective on Covalent Hit Identification and Validation in the European Pharmaceutical Industry. [PDF]

Chembiochem
Schadt O, Essig S, Testolin G.
europepmc   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Age-based stereotypes in hiring and training: how digitalization and labor shortages reshape employer decisions. [PDF]

Eur J Ageing
Heyer P, Schmitz W, Weis K.
europepmc   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

A dataset for material-specific packaging volumes in Finland in 2020. [PDF]

Data Brief
Jylhä H, Johansson A, Salminen J.
europepmc   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Functional performance tests in male and female professional dancers from four classical ballet companies - a cohort study. [PDF]

BMC Sports Sci Med Rehabil
Arens T, Hauschild A, Richter M, Fohrmann D, Zech A, Junge A.   +5 more
europepmc   +1 more source

Transitions to Sociobioeconomy in the Amazon: Governance, Business, and Sustainable Innovations. [PDF]

Environ Manage
Saes MSM, de Mello AM, Feitosa ERM, Fernandes JAL, Dos Santos ZJCG, Hamza KM.   +5 more
europepmc   +1 more source

Assessing the predictive potential of the Holstein bovine sperm methylome for bull fertility using machine learning. [PDF]

Genet Sel Evol
Asset A, Costes V, Fouéré C, Raja-Ravi-Shankar A, Danvic CL, Jaffrézic F, Kiefer H, Makowski D.   +7 more
europepmc   +1 more source

The survival of the group of companies and a one-man company

The Sociology of Law, 1988
openaire   +1 more source