Results 81 to 90 of about 178,758 (268)

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp   +4 more
wiley   +1 more source

Extraterritorial prospecting and territory defence in cooperatively breeding meerkats

open access: yes, 2012
In group living animals where natal dispersal is delayed, prospecting allows individuals to asses their future dispersal and breeding opportunities and, in males of some species, may minimize the costs of delaying dispersal by enabling extra-group ...

core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Uniform continuity in definable groups

open access: yes, 2018
"The aim of the thesis is try to give a notion of uniform continuity compatible with the definable sets of a definable group. To do this we propose the notion of product sigma-continuous function and we show that, provided that G is enough saturated, the
Suárez Sanabria, Luis Carlos
core   +2 more sources

Effects of replacing fishmeal with Spirulina platensis powder on the Zig-zag eel (Mastacembelus armatus): Growth performance, flesh quality, digestibility, and gut microbial composition

open access: yesAquaculture Reports
Protein demand from aquaculture exacerbates environmental pressures. Zig-zag eel (Mastacembelus armatus, MA) is a new aquaculture species in southern China and has great potential for future promotion.
Di Sun   +5 more
doaj   +1 more source

On partially saturated formations of finite groups.

open access: yes, 2007
This thesis deals with finite groups. More precisely, it studies formations, which are classes of groups closed under taking homomorphic images and subdirect products.
Calvo López, Clara
core  

Methane prediction based on individual or groups of milk fatty acids for dairy cows fed rations with or without linseed [PDF]

open access: yes, 2019
Milk fatty acids (MFA) are a proxy for the prediction of CH4 emission from cows, and prediction differs with diet. Our objectives were (1) to compare the effect of diets on the relation between MFA profile and measured CH4 production, (2) to predict CH4 ...
Tuchscherer, Armin   +9 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

The Ambassador and the Grotto: Landscape, Religion, and Indigeneity in Seventeenth-Century Cyclades

open access: yesArchitectural Histories
This essay examines the ceremonial visit of Charles-Marie-François Olier, Marquis de Nointel, Louis XIV’s ambassador to the Ottoman Empire, to the island of Antiparos in 1673.
Demetra Vogiatzaki
doaj   +2 more sources

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