Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
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Leveraging a Dual-Focused Growth Mindset to Boost Employee Resilience and Work Well-Being: Evidence From a Two-Wave Survey and an Intervention Study. [PDF]
Stress HealthSiu OL, Yang Y, Li A, Wang H, Ng TK.
europepmc +1 more source
Controlled Growth en masse (Somatic Growth) of Embryonic Chick Tissue in vitro
, 1914 David M. Thomson
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
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Personal Growth Among Pregnant Women During War: The Role of Optimism and Meaning in Life. [PDF]
Int J PsycholMijalevich-Soker E +5 more
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Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?
Molecular Oncology, EarlyView.Chen‐xi Li, Zhong‐cheng Gong
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Reconstructing History: Scale Analysis Reveals Long-Term Changes in Age-Related Growth of a Coregonid Fish. [PDF]
Ecol EvolVogelmann C +4 more
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The Treatment of Inoperable Growths of the Nose and Throat by Radium [PDF]
, 1914 Wm. Hill
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Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
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