Results 201 to 210 of about 23,882,396 (395)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The acute-phase protein alpha 1-antitrypsin inhibits growth and proliferation of human early erythroid progenitor cells (burst-forming units-erythroid) and of human erythroleukemic cells (K562) in vitro by interfering with transferrin iron uptake [PDF]

, 1994
I Graziadei, S. Gaggl, R Kaserbacher, H Braunsteiner, W. Vogel   +4 more
openalex   +1 more source

Growth and growth charts. [PDF]

BMJ, 1980
W E, Svensson, E, McDermott, M, O'Gorman
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Comparison of the Effects of Early andConventional Defoliation on Fruit Growth, Qualityand Skin Color Development in ‘Fuji’ Apples

, 2017
Kazuhiro Matsumoto, Tomomichi Fujita, Saki Sato, Jong‐Pil Chun   +3 more
openalex   +1 more source

A finite element method for crack growth without remeshing

, 1999
N. Moës, J. Dolbow, T. Belytschko
semanticscholar   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Defining metabolic niches for marine microbial heterotrophs. [PDF]

Sci Adv
Reynolds RC, Weiss ACB, James CC, Kojima CY, Weissman JL, Thrash JC, Levine NM.   +6 more
europepmc   +1 more source

Fruit Growth, Sugar, and Acid Characteristic in Leafy and Leafless Fruits of Satsuma Mandarin [PDF]

, 2012
Sat-Byul Kim, Eun Ui Oh, Jae Hyeon Park, Su Hyun Yun, Hyun Woo Oh, Jong Hoon Kang, Sang Wook Koh, Hyun Jeong Oh, Kwan Jeong Song   +8 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source