Results 101 to 110 of about 1,706,938 (308)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Pendapatan Akuntansi Dan Harga Saham Terhadap Pertumbuhan Dalam Produk Domistik Bruto (PDB)

open access: yesEl-Jizya: Jurnal Ekonomi Islam, 2020
The purpose of this research is to find out whether accounting income and stock prices can influence the movement of GDP growth. This study uses quantitative research methods, with up to 4 companies listed on the stock exchange using quarterly data from
Ahmad Junidi, Slamet Haryono
doaj  

Accounting for Growth in Post-Soviet Russia [PDF]

open access: yes
In pursuit of its transition from a command to a market economy, post-Soviet Russia has witnessed enormous regional differences in economic growth rates.
Daniel Berkowitz and David N. DeJong   +1 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Negative aggregate accounting earnings and gross domestic product: A perspective of conditional accounting conservatism at the macroeconomic level

open access: yesJema: Jurnal Ilmiah Bidang Akuntansi dan Manajemen
This study explores the role of corporate accounting earnings in predicting GDP growth at a macroeconomic level. It investigates whether negative aggregate accounting earnings are more effective predictors of GDP growth than positive earnings and how ...
Sari Atmini, Arum Prastiwi
doaj   +1 more source

DETERMINANT ANALYSIS IN ACCOUNTING CONSERVATISM

open access: yesRussian Journal of Agricultural and Socio-Economic Sciences, 2020
This study aims to analyze the effect of managerial ownership structure, growth opportunities, leverage, and financial distress on accounting conservatism in manufacturing companies, especially the various industrial sectors and consumer goods in the ...
Wijayanti I.   +2 more
doaj   +1 more source

Infrastructure and economic growth in the Middle East and North Africa [PDF]

open access: yes
This paper analyzes the impact of infrastructure on growth of total factor productivity and per capita income, using both growth accounting techniques and cross-country growth regressions.
Straub, Stephane   +2 more
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Política Fiscal, Choques de Oferta e a Expansão Econômica de 2003-2007

open access: yesBBR: Brazilian Business Review, 2014
Este artigo possui dois objetivos. O primeiro é mostrar o impacto de impostos distorcivos sobre um período do ciclo econômico no Brasil. O segundo é mostrar que uma explicação para o crescimento do produto abaixo do crescimento da produtividade seria o ...
Roberto Ellery Jr, Victor Gomes
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

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