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Growth Cone Motility and Guidance

Annual Review of Cell Biology, 1988
CONTENTS INTRODUCTION 43 SHAPE AND MOVEMENT: What are Growth Cones Really Like? 44 ULTRASTRUCTURE: Evidence of Membrane Recycling .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . . 46 COMPOSITION: Do Growth Cone Specific Molecules Exist? ... . . . . . . . .... 47 PHYSIOLOGY: Ionic Signals That Stop a
D, Bray, P J, Hollenbeck
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Nerve growth cone motility

Current Opinion in Cell Biology, 1990
Although many issues remain unresolved, the past year has witnessed a number of advances in our understanding of the inter-relationships between extracellular influences, cell phenotype, growth associated proteins, second messengers, and cytoskeletal components in the control of neurite outgrowth and growth cone behavior.
K, Lankford, C, Cypher, P, Letourneau
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Vesicular movements in the growth cone

Neurochemistry International, 2018
Growth cones, which are the highly motile tips of extending neuronal processes in developing neurons, have many vesicles. These vesicles are likely essential for the membrane expansion that is required for nerve growth, and probably coordinate with rearrangement of the cytoskeletons.
Motohiro Nozumi, Michihiro Igarashi
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Regulation of growth cone motility

Cell Motility, 1991
Nerve growth cones are the motile tips of elongating axons and dendrites. The migration and behavior of growth cones are responsible for axonal pathfinding to synaptic targets, and for the branching patterns of dendritic trees. Growth cones are studied at all levels of organization, molecular, cellular, and within intact embryos. Preparations of growth
P C, Letourneau, C, Cypher
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Growth Cone Collapse Assay

2013
Growth cone collapse is an easy and efficient test for detecting and characterizing axon guidance activities secreted or expressed by cells. It can also be used to dissect signaling pathways by axon growth inhibitors and to isolate therapeutic compounds that promote axon regeneration.
Xin, Yue   +2 more
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Growth cone responses to growth and chemotropic factors

European Journal of Neuroscience, 2008
AbstractDuring nervous system development axons reach their target areas under the influence of numerous guidance cues that affect rate and direction of growth. This report addresses the unsettled question of whether and to what extent growth velocity and turning responses (attraction, repulsion) are interdependent.
Staci D, Sanford   +3 more
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Microtubule organization in growth cones

Biochemical Society Transactions, 1991
Neuronal growth cones guide growing axons and dendrites (neurites) through developing embryos by detecting extrinsic guidance cues and transducing the signal into changes in motile behavior. In this chapter, the role of the growth cone cytoskeleton in these events, in particular the microtubules, is discussed.
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Microtubules and growth cone function

Journal of Neurobiology, 2003
AbstractIt has been recognized for a long time that the neuronal cytoskeleton plays an important part in neurite growth and growth cone pathfinding, the mechanism by which growing axons find an appropriate route through the developing embryo to their target cells.
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Neuronal growth cone migration

Experientia, 1990
The neuronal growth cone is a semi-autonomous portion of the developing neuron that is highly specialized for motile activity. Migrating neurons may share some features with neuronal growth cones. I review some of what has been learned about growth cone initiation, the differentiation of axons and dendrites, the role of the cytoskeleton in motility ...
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Growth Cone Collapse Assay

2014
The growth cone collapse assay has proved invaluable in detecting and purifying axonal repellents. Glycoproteins/proteins present in detergent extracts of biological tissues are incorporated into liposomes, added to growth cones in culture and changes in morphology are then assessed.
Geoffrey M W, Cook   +2 more
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