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Current Biology, 1992
Neurons obtain their stereotyped morphologies and connections as a result of growth cone migration. In the past year, studies on growth cone migration and pathfinding have helped to define certain properties of cytoskeletal filaments and cell membranes that may be important in growth cone function.
Paul C. Letourneau, Christopher Cypher
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Neurons obtain their stereotyped morphologies and connections as a result of growth cone migration. In the past year, studies on growth cone migration and pathfinding have helped to define certain properties of cytoskeletal filaments and cell membranes that may be important in growth cone function.
Paul C. Letourneau, Christopher Cypher
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Current Opinion in Neurobiology, 1991
The exact nature of growth cone motility is far from understood but progress has been made in several areas. It now appears that growth cones pull and not push; we will review the biophysical basis of growth cone movement. Current ideas on the regulation of growth cone motility and the relationship between motility and axon pathfinding are also ...
Steven R. Heidemann, Robert E. Buxbaum
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The exact nature of growth cone motility is far from understood but progress has been made in several areas. It now appears that growth cones pull and not push; we will review the biophysical basis of growth cone movement. Current ideas on the regulation of growth cone motility and the relationship between motility and axon pathfinding are also ...
Steven R. Heidemann, Robert E. Buxbaum
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Trends in Neurosciences, 2008
Wiring up the nervous system depends on the precise guidance of axonal growth cones to their targets. A key mechanism underlying this guidance is chemotaxis, whereby growth cones detect and follow molecular gradients. Although recent work has uncovered many of the molecules involved in this process, the mechanisms underlying chemotactic axon guidance ...
Mortimer, Duncan +4 more
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Wiring up the nervous system depends on the precise guidance of axonal growth cones to their targets. A key mechanism underlying this guidance is chemotaxis, whereby growth cones detect and follow molecular gradients. Although recent work has uncovered many of the molecules involved in this process, the mechanisms underlying chemotactic axon guidance ...
Mortimer, Duncan +4 more
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Trends in Neurosciences, 1989
The growth cone is a crucial structure in effecting neurite elongation and guiding the neurite onto correct pathways by responding to environmental cues. Recently developed techniques in light and electron microscopy have greatly improved our understanding of the dynamic organization of membrane and cytoskeleton within the growth cone.
Donald W. Burmeister, Daniel J. Goldberg
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The growth cone is a crucial structure in effecting neurite elongation and guiding the neurite onto correct pathways by responding to environmental cues. Recently developed techniques in light and electron microscopy have greatly improved our understanding of the dynamic organization of membrane and cytoskeleton within the growth cone.
Donald W. Burmeister, Daniel J. Goldberg
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Growth cone-growth cone interactions in cultures of rat sympathetic neurons
Developmental Biology, 1989Growth cones of sympathetic neurons from the superior cervical ganglia of neonatal rats were studied using video-microscopy to determine events following contact between growth cones and other cell surfaces, including other growth cones and neurites. A variety of behaviors were observed to occur upon contact between growth cones.
Jonathan K. Ivins, Randall N. Pittman
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Science, 1998
Growth cones are the specialized tips of neuronal axons that make their way through the nervous system in search of a correct target. In his Perspective, Caroni outlines the signaling mechanisms that help steer the growth cone as it moves, and discusses a report by Song et al .
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Growth cones are the specialized tips of neuronal axons that make their way through the nervous system in search of a correct target. In his Perspective, Caroni outlines the signaling mechanisms that help steer the growth cone as it moves, and discusses a report by Song et al .
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Growth Cone Motility and Guidance
Annual Review of Cell Biology, 1988CONTENTS INTRODUCTION 43 SHAPE AND MOVEMENT: What are Growth Cones Really Like? 44 ULTRASTRUCTURE: Evidence of Membrane Recycling .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . . 46 COMPOSITION: Do Growth Cone Specific Molecules Exist? ... . . . . . . . .... 47 PHYSIOLOGY: Ionic Signals That Stop a
Peter J. Hollenbeck, D Bray
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Current Opinion in Cell Biology, 1990
Although many issues remain unresolved, the past year has witnessed a number of advances in our understanding of the inter-relationships between extracellular influences, cell phenotype, growth associated proteins, second messengers, and cytoskeletal components in the control of neurite outgrowth and growth cone behavior.
Paul C. Letourneau +2 more
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Although many issues remain unresolved, the past year has witnessed a number of advances in our understanding of the inter-relationships between extracellular influences, cell phenotype, growth associated proteins, second messengers, and cytoskeletal components in the control of neurite outgrowth and growth cone behavior.
Paul C. Letourneau +2 more
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Growth Cone Collapse Assay [PDF]
, 2014 The growth cone collapse assay has proved invaluable in detecting and purifying axonal repellents. Glycoproteins/proteins present in detergent extracts of biological tissues are incorporated into liposomes, added to growth cones in culture and changes in morphology are then assessed.
Roger J. Keynes +2 more
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Vesicular movements in the growth cone
Neurochemistry International, 2018Growth cones, which are the highly motile tips of extending neuronal processes in developing neurons, have many vesicles. These vesicles are likely essential for the membrane expansion that is required for nerve growth, and probably coordinate with rearrangement of the cytoskeletons.
Motohiro Nozumi, Michihiro Igarashi
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