Results 161 to 170 of about 11,150,175 (351)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Economic growth and carbon dioxide emissions: Empirical evidence from China [PDF]
Using time series data, this paper investigates China’s carbon emissions during 1960-2006, with particular focus on the direct role of growth and in connection to trade and the value added by various sectors like agriculture, industry and services.
Halkos, George, Tzeremes, Nickolaos
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
OPTIMAL SIZE OF GOVERNMENT AND ECONOMIC GROWTH IN EU-27 [PDF]
Using time-series techniques and panels data, the paper analyses for the EU countries in the period 1970-2009 the existence and shape of the "BARS curve" (Barro, Armey, Rahn, and Scully), connecting the size of Government (measured by the share of public
Cosimo Magazzino, Francesco Forte
core
Application of Latent Growth Curve Analysis With Categorical Responses in Social Behavioral Research
Structural equation modeling : a multidisciplinary journal, 2018 T. Lee, K. Wickrama, C. O’Neal
semanticscholar +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Phillips Curves and Unemployment Dynamics: A Critique and a Holistic Perspective [PDF]
The conventional wisdom that inflation and unemployment are unrelated in the long-run implies the compartmentalisation of macroeconomics. While one branch of the literature models inflation dynamics and estimates the unemployment rate compatible with ...
Dennis J. Snower +2 more
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Measuring Pro-Poor Progress towards the Non-Income Millennium Development Goals [PDF]
In order to track progress in MDG1 and explicitly link growth, inequality, and poverty reduction, several measures of \"pro-poor growth\" have been proposed in the literature and used in applied academic and policy work.
Kenneth Harttgen +2 more
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