Results 281 to 290 of about 304,424 (378)

Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

Advanced Science, EarlyView.
Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan, Jingyi Qi, Yi Xia, Chang Fan, Teng Xu, Xu Zhang, Jiaxin Shi, Chenxuan Wang, Yitong Cheng, Dongyuan Zhang, Rong Liu, Yinhua Zhu, Changchang Cao, Dekui Jin, Peng An, Yongting Luo, Junjie Luo   +16 more
wiley   +1 more source

Recombinant growth hormone improves growth and adult height: a comparison between treated and untreated patients with idiopathic growth hormone deficiency. [PDF]

Transl Pediatr
Zhao Q, Li R, Shao Q, Zhang M, Ban B.
europepmc   +1 more source

The Severity of Growth Hormone Deficiency (GHD) in Adult Pituitary Disease is Related to the Degree of Hypopituitarism

, 1994
Andrew Toogood, C G Beardwell, Stephen M. Shalet   +2 more
openalex   +2 more sources

Urinary growth hormone estimation in diagnosing severe growth hormone deficiency. [PDF]

, 1996
Piero Pirazzoli, M Mandini, Stefano Zucchini, Stefano Gualandi, L Vignutelli, Giovanni Capelli, E Cacciari   +6 more
openalex   +1 more source

Gut Microbiota Modulates Obesity‐Associated Skeletal Deterioration Through Macrophage Aging and Grancalcin Secretion

Advanced Science, EarlyView.
Obese gut‐microbiota derived lipopolysaccharides (LPS) induce bone marrow macrophage senescence and GCA secretion via activating TLR4/NF‐κB/MAPKs pathway. Clinically, obese patients are associated with higher serum GCA levels. Mice with depletion of GCA gene show resistance to skeletal deterioration caused by obesity and LPS‐induced chronic ...
Min Huang, Mei Huang, Ling Liu, Fang Yang, Chen He, Yu‐Chen Sun, Yu‐Rui Jiao, Xiang Tang, Jing Hou, Kai‐Xuan Chen, Wen‐Zhen He, Jie Wei, Hui‐Ling Chen, Xia Li, Chao Zeng, Guang‐Hua Lei, Chang‐Jun Li   +16 more
wiley   +1 more source

Screening for Growth Hormone Deficiency in Three-year-old Children

, 1993
Shigeki Miyamoto, Nozomu Sasaki, Hiroshi Ikegami   +2 more
openalex   +2 more sources

Low‐Coordination Configuration Single‐Atom Manganese Nanozymes for NIR‐Imaging‐Oriented Efficient Catalytic Oncotherapy

Advanced Science, EarlyView.
The manuscript designs a type of SA Mn‐CDs with low coordination Mn‐N2 configuration hydrothermally synthesized by chelating manganese atoms with ethylenediamine tetraacetic acid. SA Mn‐CDs not only have more active sites at the atomic level for high efficiently peroxidase‐like activity but also show excellent fluorescent ability at the cellular and ...
Peiwei Jin, Dandan Wang, Yijun Lu, Yong Qian, Chengyang Fang, Xiaoxiao Zhang, Junchao Qian, Songnan Qu, Hui Wang   +8 more
wiley   +1 more source

The interplay of immunity and growth: a case of combined variable immunodeficiency and growth hormone deficiency. [PDF]

Ann Med Surg (Lond)
Majety SK, Modh S, Mishra D, Alam N, Suvvari TK, Pagadala CGM, Muppana G.   +6 more
europepmc   +1 more source

Isolated Growth Hormone Deficiency Type 1A without Apparent Growth Hormone 1 Gene Deletion

, 1994
Shinya Tamai, Nobutake Matsuo, Seiji Sato, Jun Kudoh, Nobuyoshi Shimizu   +4 more
openalex   +2 more sources

Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles

Advanced Science, EarlyView.
Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang, Shiying Zhang, Irene Shuping Zhao, Xueqi Gan, Yang Zhang   +4 more
wiley   +1 more source