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Genetics of Growth Hormone Deficiency
Endocrinology and Metabolism Clinics of North America, 2007When a child is not following the normal, predicted growth curve, an evaluation for underlying illness and central nervous system abnormalities is required and appropriate consideration should be given to genetic defects causing growth hormone (GH) deficiency.
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Diagnosis of Growth Hormone Deficiency
2010The diagnosis of growth hormone deficiency (GHD) was essentially a clinical one prior to the advent of radioimmunoassay in the mid-1960s. From this point on both clinical and biochemical serum GH responses to a variety of provocation tests were used to define the condition. The definition of an adequate GH response to stimulation has changed over time,
E.A. Webb, Mehul T. Dattani
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Diagnosis of growth-hormone deficiency in adults
The Lancet, 1994There is no consensus as to the most appropriate method of diagnosing growth-hormone (GH) deficiency in adults. We have evaluated the relative diagnostic merits of measuring peak GH response to insulin-induced hypoglycaemia (insulin tolerance test), mean 24 h GH concentration derived from 20 min sampling, serum insulin-like growth factor I (IGF-I ...
Anthony J O'Sullivan +7 more
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Growth hormone replacement for adult growth hormone deficiency
Expert Opinion on Pharmacotherapy, 2003Growth hormone deficiency (GHD) in childhood causes growth retardation, short stature and significant impairment of adult height. Growth hormone (GH) has been given successfully to these children for > 40 years but only since the introduction of recombinant DNA technology, has enough GH been available for paediatric needs and also for other indications.
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A case of pycnodysostosis with growth hormone deficiency
Clinical Genetics, 1996Pycnodysostosis is a skeletal dysplasia characterized by short stature. Treatment of pycnodysostosis with growth hormone (GH) has not been reported so far. We describe a case of pycnodysostosis with growth hormone deficiency in addition to low mean insulin‐lüce growth factor 1 (IGF‐1) concentration.
Darcan, S +3 more
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Adult Growth Hormone Deficiency
2002Adult-onset growth hormone deficiency (GHD) is a rare disease with an exact incidence that is not currently known, but indirect estimates based on the incidence of pituitary tumors suggest an incidence of 10 people per million annually (1). Over the last decade the adverse metabolic and psychological sequelae of adult GHD have been increasingly ...
James W. Edmondson, Zehra Haider
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Detection of Growth-Hormone Deficiency
New England Journal of Medicine, 1970Abstract After injection of glucagon, growth hormone increased to 8.0 ng per milliliter or more in 33 of 34 subjects without apparent pituitary disease. In 21 of 23 patients with pituitary disease the maximum value did not exceed 4.8 ng per milliliter. The glucagon stimulation test is a safe, convenient and reasonably reliable way of testing for growth-
Y Sanchez +3 more
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Growth hormone deficiency in children
Best Practice & Research Clinical Endocrinology & Metabolism, 2016PRODAM, Flavia +2 more
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Growth Hormone Therapy in Adults with Growth Hormone Deficiency [PDF]
Acta Paediatrica, 1991 R.C. Cuneo +9 more
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