Results 111 to 120 of about 450,220 (290)
Parameter estimation of Stochastic Logistic Model : Levenberg-Marquardt Method [PDF]
, 2009 In this paper, we estimate the drift and diffusion parameters of the stochas- tic logisticmodels for the growth of Clostridium Acetobutylicum P262 using Levenberg- Marquardt optimization method of non linear least squares.
Abd. Rahman, Haliza +5 more
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2020 Model‐informed drug development (MIDD) approaches have rapidly advanced in drug development in recent years. Additionally, the Prescription Drug User Fee Act (PDUFA) VI has specific commitments to further enhance MIDD. Tumor growth dynamic (TGD) modeling,
Nidal Al‐Huniti +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
BMC Infectious DiseasesBackground Heart rate is one of the important vital signs. Many studies have done a lot of meaningful research on heart rate in sepsis patients. However, the heart rates of sepsis patients were repeatedly measured after their admission to intensive care ...
Wenming Shao +7 more
doaj +1 more source
Formal and Informal Model Selection with Incomplete Data
, 2008 Model selection and assessment with incomplete data pose challenges in addition to the ones encountered with complete data. There are two main reasons for this.
Beunckens, Caroline +2 more
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Overview of Combustion Instabilities in Liquid-Propellant Rocket Engines [PDF]
, 1995 N/
Culick, Fred E. C., Yang, Vigor
core