Results 71 to 80 of about 450,220 (290)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Trajectory prediction model of diabetes distress in adults with type 2 diabetes mellitus: a 12-month prospective longitudinal study

Frontiers in Psychology
IntroductionClarifying heterogeneous diabetes distress (DD) trajectories and their predictors from a dynamic perspective is crucial. We aimed to develop a trajectory prediction model for dynamic DD.MethodsThis prospective longitudinal study included 443 ...
Yu-Yun Zhang, Yu-Yun Zhang, Wei Li, Qing-Yan Wang, Fang Zhao, Qun Wang, Yu Sheng   +6 more
doaj   +1 more source

The longitudinal interplay between negative and positive symptom trajectories in patients under antipsychotic treatment: a post hoc analysis of data from a randomized, 1-year pragmatic trial [PDF]

, 2013
BACKGROUND: Schizophrenia is a highly heterogeneous disorder with positive and negative symptoms being characteristic manifestations of the disease. While these two symptom domains are usually construed as distinct and orthogonal, little is known about ...
Ascher-Svanum, H, Chen, L, Johnston, JA, Kinon, BJ, Marques, TR, Stauffer, V, Succop, P   +6 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Modifiable factors associated with a consistently high acute pain trajectory after surgical treatment of traumatic fractures in Ethiopia: a multi-center prospective cohort study

Journal of Orthopaedic Surgery and Research, 2023
Background In Ethiopia, little is known about postoperative pain trajectories and possible predictive factors associated with them in patients undergoing surgery following traumatic fractures.
Mestawet Getachew, Anners Lerdal, Milada Cvancarova Småstuen, Million Tesfaye Eshete, Tilahun Desta, Maren Falch Lindberg   +5 more
doaj   +1 more source

The use of artificial neural networks in adiabatic curves modeling [PDF]

, 2008
Adiabatic hydration curves are the most suitable data for temperature calculations in concrete hardening structures. However, it is very difficult to predict the adiabatic hydration curve of an arbitrary concrete mixture.
Kavčič, Franci, Trtnik, Gregor, Turk, Goran   +2 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

A Note on the Interpretation of Scale Values in Multidimensional Scaling Growth Analysis

Journal of Methods and Measurement in the Social Sciences, 2011
Multidimensional Scaling (MDS) has been used as a growth mixture modeling technique in psychological and education research in recent years. This note focuses on a detailed explanation of interpreting the scale values in MDS growth analysis.
Cody Ding
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Modeling and visualizing uncertainty in gene expression clusters using Dirichlet process mixtures [PDF]

, 2009
Although the use of clustering methods has rapidly become one of the standard computational approaches in the literature of microarray gene expression data, little attention has been paid to uncertainty in the results obtained. Dirichlet process mixture (
De la Cruz, Bernard J., Ghahramani, Zoubin, Rasmussen, Carl Edward, Wild, David L.   +3 more
core   +1 more source