Results 81 to 90 of about 450,220 (290)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Joint Clustering and Registration of Functional Data [PDF]
, 2014 Curve registration and clustering are fundamental tools in the analysis of functional data. While several methods have been developed and explored for either task individually, limited work has been done to infer functional clusters and register curves ...
Telesca, Donatello, Zhang, Yafeng
core
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
From a thin film model for passive suspensions towards the description of osmotic biofilm spreading
, 2016 Biofilms are ubiquitous macro-colonies of bacteria that develop at various interfaces (solid-liquid, solid-gas or liquid-gas). The formation of biofilms starts with the attachment of individual bacteria to an interface, where they proliferate and produce
John, Karin +2 more
core +3 more sources
A hierarchical model to estimate the abundance and biomass of salmonids by using removal sampling and biometric data from multiple locations [PDF]
, 2010 We present a Bayesian hierarchical model to estimate the abundance and the biomass of brown trout (Salmo trutta fario) by using removal sampling and biometric data collected at several stream sections.
Laplanche, Christophe, Ruiz, Philippe
core +4 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications [PDF]
, 2009 Resorting to a multiphase modelling framework, tumours are described here as a mixture of tumour and host cells within a porous structure constituted by a remodelling extracellular matrix (ECM), which is wet by a physiological extracellular fluid.
A Bertuzzi +49 more
core +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Covariance pattern mixture models for the analysis of multivariate heterogeneous longitudinal data
, 2015 We propose a novel approach for modeling multivariate longitudinal data in the presence of unobserved heterogeneity for the analysis of the Health and Retirement Study (HRS) data.
Anderlucci, Laura, Viroli, Cinzia
core +1 more source
Formation rates of complex organics in UV irradiated CH3OH-rich ices I: Experiments [PDF]
, 2009 (Abridged) Gas-phase complex organic molecules are commonly detected in the warm inner regions of protostellar envelopes. Recent models show that photochemistry in ices followed by desorption may explain the observed abundances.
Garrod, R. T. +3 more
core +1 more source