Results 131 to 140 of about 7,576,972 (305)

Türkiye’de Makro İhtiyati Para Politikası Araçlarının Makroekonomik Değişkenlere Etkisinin VAR Analizi ile İncelenmesi

open access: yesİstanbul İktisat Dergisi, 2017
Bu çalışmanın amacı, Türkiye Cumhuriyet Merkez Bankası’nın (TCMB) 2008 Finansal Kriz sonrası makro ihtiyati para politikası uygulamalarının etkisini analiz etmektir.
Nadir EROĞLU, Funda KARA
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Modeling Limits to Growth

open access: yes, 2016
This chapter introduces system dynamics models of limits to growth. First, a one-stock model is presented, where the growth rate varies, and is influenced by the system’s carrying capacity. Second, a model of economic growth is described, which captures the law of diminishing returns, a feature of many economic systems.
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Closed form solutions to a generalization of the Solow growth model. [PDF]

open access: yes
The Solow growth model assumes that labor force grows exponentially. This is not a realistic assumption because, exponential growth implies that population increases to infinity as time tends to infinity.
Erick José Limas Maldonado   +1 more
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Optimal forest harvesting policy using dynamic programming method (Case study: Shafarod forest) [PDF]

open access: yesمجله جنگل ایران, 2013
The aim of this research is to determine the optimal harvesting using dynamic programming in Shafarod forests at Guilan province.  First of all, a logistic growth function was used to predict the growth model.
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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