Results 141 to 150 of about 1,814,562 (269)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

On Discretely Structured Growth Models and Their Moments. [PDF]

Bull Math Biol
Walker BJ, Byrne HM.
europepmc   +1 more source

Investigating the Ability of Growth Models to Predict In Situ Vibrio spp. Abundances. [PDF]

Microorganisms, 2022
Purgar M, Kapetanović D, Geček S, Marn N, Haberle I, Hackenberger BK, Gavrilović A, Pečar Ilić J, Hackenberger DK, Djerdj T, Ćaleta B, Klanjscek T.   +11 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Compatible versus annual stand-growth models for thinned Chinese fir plantations. [PDF]

Front Plant Sci
Jiang Y, Cao QV, Chen J, Zhang J, Zhang X.   +4 more
europepmc   +1 more source

Comparison of Nonlinear Growth Models to Estimate Growth Curves in Kivircik Sheep under a Semi-Intensive Production System. [PDF]

Animals (Basel), 2023
Ozturk N, Kecici PD, Serva L, Ekiz B, Magrin L.   +4 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The Developmental Trajectory of Learned Helplessness in Breast Cancer Chemotherapy Patients: A Longitudinal Study Based on Latent Growth Models. [PDF]

Patient Prefer Adherence
Li X, Guo Z, Jiao Y, Lu Y, Ding S, Li X, Yang R, Chen C.   +7 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Inverse Problem Regularization for 3D Multi-Species Tumor Growth Models. [PDF]

Int J Numer Method Biomed Eng
Ghafouri A, Biros G.
europepmc   +1 more source