Results 101 to 110 of about 175,458,867 (287)

Infinite growth of solutions of second order complex differential equation

Open Mathematics, 2018
In this paper we study the growth of solutions of second order differential equation f′′ + A(z)f′ + B(z)f = 0. Under certain hypotheses, the non-trivial solution of this equation is of infinite order.
Zhang Guowei
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Growth of solutions of higher-order linear differential equations

Electronic Journal of Differential Equations, 2010
In this article, we study the growth of solutions of the linear differential equation $$ f^{(k)}+(A_{k-1}(z)e^{P_{k-1}(z)}+B_{k-1}(z)) f^{(k-1)}+dots +(A_0(z)e^{P_0(z)}+B_0(z))f=0, $$ where $kgeq 2$ is an integer, $P_j(z)$ are nonconstant ...
Karima Hamani
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Growth of solutions to linear differential equations with entire coefficients of slow growth

Electronic Journal of Differential Equations, 2010
In this article, we investigate the hyper order of solutions of higher-order linear differential equations with entire coefficients of slow growth. We assume that the lower order of the dominant coefficient in the high-order linear equations is less ...
Cui-Yan Zhang, Jin Tu
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Growth of solutions to second-order complex differential equations

Electronic Journal of Differential Equations, 2014
In this article, we study the existence of non-trivial subnormal solutions for second-order linear differential equations. We show that under certain conditions some differential equations do not have subnormal solutions, also that the hyper-order ...
Nan Li, Lianzhong Yang
doaj  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source