Results 81 to 90 of about 392,244 (268)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Linnemannia elongata: A Key Species in Chitin-Based Plant Growth Promotion

Phytobiomes Journal
Chitin has proven to be a valuable alternative to mineral fertilizers in growing media. We recently hypothesized that chitin might work as a biostimulant, attracting plant growth-promoting microbes to the rhizosphere.
Caroline De Tender, Michiel Vandecasteele, Sarah Ommeslag, Noémie De Zutter, Ellen Vandenbussche, Annelies Haegeman, Kris Audenaert, Leilei Li, Bart Vandecasteele, Floris Voorthuijzen, Kristof Maenhout, Stien Beirinckx, Rosita Barneveldt, Sofie Goormachtig, Jane Debode   +14 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Selenium promotes soybean sprout growth via enhanced antioxidant capacity and nutrient mobilisation

Plant, Soil and Environment
Selenium (Se) biofortification of soybean sprouts presents a promising approach for enhancing dietary Se intake. However, the physiological mechanisms of Se promoting growth remain poorly understood. Here, we investigated the effects of selenite (Na2SeO3)
Kaiwei Li, Lele Li, Yuqing Liu, Sanchun Lei, Minghao Hao, Qiong Wu, Feiyan Yu, Lianhe Zhang   +7 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Eco-Beneficial Biocontrol Agents for Mitigating Rice Blast and Enhancing Growth and Yield

Caraka Tani: Journal of Sustainable Agriculture
Rice blast disease, caused by Magnaporthe oryzae, is a major threat to global rice production. Eco-friendly biocontrol agents offer a sustainable alternative to chemical fungicides for managing this disease.
Sayera khatun, Mst. Habiba Tamanna, Md Mahmodol Hasan   +2 more
doaj   +1 more source