Results 191 to 200 of about 2,549,300 (265)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Clinical Implications of Stroke Progressor Phenotypes defined based on ASPECTS decay and perfusion estimated infarct growth rate: insights from a large national thrombectomy registry. [PDF]

Neurol Sci
Ciacciarelli A, Nicolini E, Saia V, Pracucci G, Pensato U, De Michele M, Benedetti L, Casetta I, Fainardi E, Marcheselli S, Da Ros V, Maestrini I, Simonetti L, Zini A, Vinci SL, La Spina P, Laiso A, Nencini P, Del Sette B, Markushi TB, Bracco S, Tassi R, Saletti A, De Vito A, Boghi A, Naldi A, Burdi N, Boero G, Vallone S, Bigliardi G, Lazzarotti GA, Giannini N, Milazzo N, Persico A, Ruggiero M, Longoni M, Menozzi R, Pezzini A, Allegretti L, Tassinari T, Mambrin F, Cappellari M, Bergui M, Bosco G, Comai A, Franchini E, Lozupone E, Caggiula M, Zimatore S, Petruzzellis M, Gallesio I, Ferrandi D, Perri M, De Santis F, Puglielli E, Casalena A, Galvano G, Saracco E, Allegritti M, Caproni S, Alberti M, Invernizzi P, Carità G, Russo M, Besana M, Giossi A, Filizzolo M, Mannino M, Pelle G, Alessiani M, Konda D, Sallustio F, Mangiafico S, Toni D.   +73 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Analysis of growth rate, haematologic, and biochemical parameters of Oncopigs. [PDF]

Int J Vet Sci Med
Elkhadragy L, Castillo CC, Li R, Bolt CR, Rund L, Thomas F, Lane R, Gaba RC, Schook LB, Schachtschneider KM.   +9 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Genetic Selection for Growth Rate Reshapes the Plasma Metabolome of Rabbit Does Derived from Vitrified Embryos: Insights into Nutrient Metabolism and Productive Efficiency. [PDF]

Vet Sci
Mateo-López J, Huertas-Herrera A, Toro-Manríquez M, Hedemann MS, Cortés-García C, Llobat L, Páez-Rosas D, Cambra-López M, Pascual JJ, Marín-García PJ.   +9 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effect of intestinal microbiota on growth rate of Babylonia areolata. [PDF]

PLoS One
Zhao W, Huang X, Qin H, Fu Z, Yang R, Deng Z, Zhu J, Wang D, Zheng Z.   +8 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Growth rate controls the sensitivity of gene regulatory circuits. [PDF]

Sci Adv
Julou T, Gervais T, de Groot D, van Nimwegen E.   +3 more
europepmc   +1 more source