Results 181 to 190 of about 2,544,711 (265)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Differential Expression and Alternative Splicing Pattern in Female and Male Groups <i>Pelteobagrus ussuriensis</i> with Different Growth Rate. [PDF]

Animals (Basel)
Sun Y, Chen J, Li P, Luo L, Zhu C.
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Clinical Implications of Stroke Progressor Phenotypes defined based on ASPECTS decay and perfusion estimated infarct growth rate: insights from a large national thrombectomy registry. [PDF]

Neurol Sci
Ciacciarelli A, Nicolini E, Saia V, Pracucci G, Pensato U, De Michele M, Benedetti L, Casetta I, Fainardi E, Marcheselli S, Da Ros V, Maestrini I, Simonetti L, Zini A, Vinci SL, La Spina P, Laiso A, Nencini P, Del Sette B, Markushi TB, Bracco S, Tassi R, Saletti A, De Vito A, Boghi A, Naldi A, Burdi N, Boero G, Vallone S, Bigliardi G, Lazzarotti GA, Giannini N, Milazzo N, Persico A, Ruggiero M, Longoni M, Menozzi R, Pezzini A, Allegretti L, Tassinari T, Mambrin F, Cappellari M, Bergui M, Bosco G, Comai A, Franchini E, Lozupone E, Caggiula M, Zimatore S, Petruzzellis M, Gallesio I, Ferrandi D, Perri M, De Santis F, Puglielli E, Casalena A, Galvano G, Saracco E, Allegritti M, Caproni S, Alberti M, Invernizzi P, Carità G, Russo M, Besana M, Giossi A, Filizzolo M, Mannino M, Pelle G, Alessiani M, Konda D, Sallustio F, Mangiafico S, Toni D.   +73 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Theoretical Analyses of Turgor Pressure and Expansive Growth Rate of Plant Cells During Water Deficit. [PDF]

Plants (Basel)
Ortega JKE.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Comparative efficacy of pharmacological agents on abdominal aortic aneurysm growth rate: a systematic review and network meta-analysis. [PDF]

Front Pharmacol
Wen C, Li L, Wang B, Xie L, Wu H.
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source