Results 131 to 140 of about 5,909,239 (281)

The degree of commitment to regulator independence: measurement and impact [PDF]

open access: yes
This study computes measures of the degree of independence in practice of telecommunications regulators for Latin American and Caribbean countries in a new data set for 23 countries between 1990 and 2004.
Miguel Angel Montoya, Francesc Trillas
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

The enigma of the vertical dimension

open access: yes, 2000
http://babel.hathitrust.org/cgi/pt?id=mdp.39015050714057;view=2up;ui=fullscreen#page/n0/mode ...
Symposium on Craniofacial Growth
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

A new use of Agrobacterium plant growth regulator genes for plant bioengineering. [PDF]

open access: yesFront Plant Sci
Heck M   +43 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy