Results 131 to 140 of about 5,785,845 (286)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Placental dysfunction drives fetal growth restriction: mechanisms and translational perspectives. [PDF]

Front Mol Biosci
He L, Hong D, Chen H, Chen X.
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Fetal growth restriction leads to prolonged nephrogenesis and gene dysregulation in the adult kidney. [PDF]

Life Sci Alliance
Timberline S, Dailey RK, Johnson W, Kameshwar AKS, Isaac J, deRonde K, Conaway M, Cwiek A, Bennett KM, Baldelomar EJ, Li T, Wu T, Hoch MR, Schuh MP, Indugula S, Seki Y, Suzuki M, Reidy KJ, Charlton JR.   +18 more
europepmc   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

The Heart of Fetal Growth Restriction: Congenital Heart Defects-An Analysis of Risk Factors and Morbidity Outcomes. [PDF]

Life (Basel)
Adam-Raileanu A, Salaru DL, Lupu A, Jechel E, Ciorpac M, Anton E, Bozomitu LI, Moisa SM, Temneanu OR, Grudnicki A, Rosu MF, Anton SC, Nedelcu AH, Cuciureanu M, Lupu VV.   +14 more
europepmc   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

First-Trimester Maternal CALLY Index Is Associated With Fetal Growth Restriction. [PDF]

Am J Reprod Immunol
Karakus E, Yahsi AF, Katipoglu K.
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Glycosylated Fibronectin in Fetal Growth Restriction: An Emerging Biomarker of Placental Dysfunction. [PDF]

Cureus
Karoutsos DI, Stefanidis K, Michala L, Antsaklis P, Mavrogianni D, Asimakopoulos G, Daskalakis G.   +6 more
europepmc   +1 more source