Results 81 to 90 of about 5,785,845 (286)

Short- and long-term reproductive effects of prenatal and lactational growth restriction caused by maternal diabetes in male rats

Reproductive Biology and Endocrinology, 2011
Background A suboptimal intrauterine environment may have a detrimental effect on gonadal development and thereby increases the risk for reproductive disorders and infertility in adult life.
Amorim Elaine MP, Damasceno Débora C, Perobelli Juliana E, Spadotto Raquel, Fernandez Carla DB, Volpato Gustavo T, Kempinas Wilma DG   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Postnatal hyperoxia or DEHP exposure leads to growth restriction and delayed lung development in newborn rats

Pediatrics and Neonatology, 2018
Background: Di-(2-ethylhexyl) phthalate (DEHP) is commonly used as a plasticizer in many medical devices. We previously showed that maternal DEHP exposure led to restricted growth and delayed lung maturation in newborn rats.
Zhong-Jie Liang, Qiu-Ping Wu, Bei-Tao Chen, Zhen-lang Lin, Jing Lin, Shang-Qin Chen   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Case Report: Growth hormone deficiency and response to treatment in MIRAGE syndrome: expanding the endocrine phenotype

Frontiers in Endocrinology
BackgroundMIRAGE syndrome, a rare autosomal dominant disorder, is caused by heterozygous gain-of-function mutations in the SAMD9 gene. A key characteristic of MIRAGE syndrome is growth restriction.
Laura Trapani, Marta Cognigni, Natalia Maximova, Erica Valencic, Alice Fachin, Gianluca Tamaro, Gianluca Tamaro, Alberto Tommasini, Alberto Tommasini, Gianluca Tornese, Gianluca Tornese   +10 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Impact of COVID-19 infection on pregnancy outcomes: A retrospective cohort study focusing on preterm and low-birth-weight pregnancies

National Journal of Physiology, Pharmacy and Pharmacology
Background: Viral infections pose significant risks to pregnant women and fetuses. Although the impact of many viruses on pregnancy has been well-documented, the specific effects of COVID-19 on gestational age and newborn development remain unclear ...
Naladala Disha Chowdary, Chaitra Madanahalli Sridhar, Usha Kantharajanna, Srinivasulu Naidu, Shravanthi Venkatesh, Arjun Santosh Menon   +5 more
doaj   +1 more source

Growth Restriction and Systemic Immune Development in Preterm Piglets

Frontiers in Immunology, 2019
Background: Many preterm infants are born with growth restriction (GR) following maternal or fetal complications before birth. Such infants may continue to grow slowly after birth, regardless of birth weight (BW), due to morbidities related to their ...
Ole Bæk, Per Torp Sangild, Thomas Thymann, Duc Ninh Nguyen   +3 more
doaj   +1 more source