Results 221 to 230 of about 5,401,070 (277)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Chemical Fusion of Gold Nanorods into Continuous Ring Nanostructures. [PDF]

Materials (Basel)
Khanal BP, Zubarev ER.
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Divergent growth and wood anatomical responses of European larch and Swiss stone pine to climate variability at alpine treeline ecotones. [PDF]

Front Plant Sci
Marotta F, Tumajer J, Begović K, Jevšenak J, Kuželová H, Lexa M, Mašek J, Obojes N, Rydval M, Treml V, Lange J.   +10 more
europepmc   +1 more source

Bioactive Constituents of <i>Piper crocatum</i> Ruiz & Pav. and <i>Piper betle</i> Linn. as Antifungal and Antibiofilm Agents Against <i>Candida albicans</i>. [PDF]

Drug Des Devel Ther
Kurnia D, Tristyaningrum NA, Herlina T, Kai K, Evangelina Iii IA.   +4 more
europepmc   +1 more source

Phase separation of ecDNA condensates establishes in-trans contact domains that boost selective MYC regulatory interactions. [PDF]

Nat Commun
Conte M, Al Hasani L, Matteuzzi T, Esposito A, Kundu S, Chiariello AM, Bianco S, Vercellone F, Li W, Nicodemi M.   +9 more
europepmc   +1 more source

Outcomes of Slide Tracheoplasty in Children: A Single-center Experience. [PDF]

J Indian Assoc Pediatr Surg
Rao S, Zameer MM, Sailavanya T, Juby NA, Rakhesh M, Vinay C, D'Cruz A.   +6 more
europepmc   +1 more source

Integration of CCT/TRiC assembly, degradation and function: Chaperonin complexity in a cellular context. [PDF]

Cell Stress Chaperones
Grantham J.
europepmc   +1 more source

Environmental Behavior, Toxicological Pathways, and Risk Assessment of Polycyclic Aromatic Hydrocarbons (PAHs): From Molecular Structure to Human Health. [PDF]

Molecules
Harasym J, Nizio E.
europepmc   +1 more source

ANNUAL RINGS OF TREE GROWTH

Monthly Weather Review, 1905
openaire   +1 more source