Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
A free-boundary model of diffusive valley growth: theory and observation. [PDF]
Proc Math Phys Eng Sci, 2017 Yi R +6 more
europepmc +1 more source
Unemployment and productivity in long-run: the role of macroeconomic volatility [PDF]
We propose a theory of low-frequency movements in unemployment based on downward real wage rigidities. The theory generates two main predictions: long-run unemployment increases with (i) a fall in long-run productivity growth and (ii) a rise in the ...
Luca Antonio Ricci +2 more
core
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Harnessing the acid growth theory to optimize apoplastic acidification for enhancing cotton fiber elongation. [PDF]
Plant CommunLi C +10 more
europepmc +1 more source
A poroelastic mixture model of mechanobiological processes in biomass growth: theory and application to tissue engineering. [PDF]
Meccanica, 2017 Sacco R, Causin P, Lelli C, Raimondi MT.
europepmc +1 more source
Engels's Second Theory: Technology, Warfare and the Growth of the State
, 2020 Wolfgang Streeck
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
The impact of R&D factors flow and regional absorptive capacity on China's economic growth: Theory and evidence. [PDF]
PLoS OneLi X, Liang F, Pi Y, Chen D.
europepmc +1 more source