Results 51 to 60 of about 1,825,008 (215)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

Clinical phenotype and trio whole exome sequencing data from a patient with glycogen storage disease IV in Indonesia(NCBI)

Data in Brief
Glycogen storage disease type IV (GSD IV) is a rare disease caused by a defect in glycogen branching enzyme 1 (GBE1), which played a crucial role in glycogen branching.
Ivan William Harsono, Yulia Ariani, Beben Benyamin, Fadilah Fadilah, Dwi Ari Pujianto, Cut Nurul Hafifah, Titis Prawitasari   +6 more
doaj   +1 more source

Nanocubes and Cuboctahedra: Entropic Stabilization Versus Thermal Segregation in Rock Salt‐ and Spinel‐Type Multinary Oxides from Spray‐Flame Synthesis

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Spray‐flame synthesis enables highly flexible and scalable production of multinary and high‐entropy oxide nanoparticles due to high synthesis temperatures with subsequent quenching. Temperature‐dependent in situ diffraction of as‐synthesized materials clearly reveals entropy stabilization in rock salt lattices, while spinels—featuring tetrahedral and ...
Mohammed‐Ali Sheikh, Steven Angel, Sabrina Schleich, Leon Müller, Jan Ternieden, Hatem M. A. Amin, Christof Schulz, Hartmut Wiggers   +7 more
wiley   +1 more source

Genetic characterization of GSD I in Serbian population revealed unexpectedly high incidence of GSD Ib and 3 novel SLC37A4 variants [PDF]

, 2017
Glycogen storage disease (GSD) type I is inborn metabolic disease characterized by accumulation of glycogen in multiple organs. We analyzed 38 patients with clinical suspicion of GSD I using Sanger and next-generation sequencing (NGS).
Klaassen, Kristel, Sarajlija, A., Spasovski, Vesna, Skakić, Anita, V. Spasovski, Pavlović, Sonja, Stojiljković, Maja, K. Klaassen, Đorđević, M., M. Djordjevic, S. Pavlovic, Ugrin, Milena, M. Ugrin, A. Sarajlija, M. Stojiljkovic, Tošić, Nataša, Kecman, B., N. Tosic, A. Skakic, B. Kecman   +19 more
core   +1 more source

Geochemistry and Geochronology of Magmatic Rocks in Southwestern and Northeastern Cambodia: Implications for the Tectonic Evolution and Metallogenesis of the Loei Fold Belt

Geological Journal, EarlyView.
The composition of intrusive rocks suggests that the magma was likely generated in a subduction‐related setting. The arc crustal thickness in the Phnom Sro Ngam and Halo Prospects was probably < 40 km during emplacement. Zircon U–Pb age range indicates a correlation with Loei Fold Belt magmatic activity.
Sirisokha Seang, Khin Zaw, Kakda Kret, Ivan Belousov, Kotaro Yonezu, Koichiro Watanabe, Charles Makoundi   +6 more
wiley   +1 more source

A Modified Enzymatic Method for Measurement of Glycogen Content in Glycogen Storage Disease Type IV

, 2016
Deficiency of glycogen branching enzyme in glycogen storage disease type IV (GSD IV) results in accumulation of less-branched and poorly soluble polysaccharides (polyglucosan bodies) in multiple tissues.
Yi, Haiqing, Haiqing Yi, Sun, Baodong, Chunyu Yang, Kishnani, Priya S, Priya S. Kishnani, Zhang, Quan, Quan Zhang, Yang, Chunyu, Baodong Sun   +9 more
core   +1 more source

Using the PMBOK® guide to frame GSD coordination strategies [PDF]

, 2013
Global software development (GSD) carried out at various locations is impeded by global distance categorized as exterior and interior. To overcome this, specific communication strategies are required to coordinate a range of activities between client and
Deshpande, Sadhana, Sadhana Deshpande, Beecham, Sarah, SARAH BEECHAM (12347308), Sarah Beecham, Ita Richardson, Sadhana Deshpande (12603946), ITA RICHARDSON (12352663), Richardson, Ita   +8 more
core   +1 more source

Soil Silicon Application Alleviates Drought Stress in Sugar Beet (Beta vulgaris L.)

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Background: The increasing frequency and intensity of drought events have led to yield and quality losses in sugar beet production in temperate regions in Central Europe. Under arid conditions, silicon (Si) application reduced beet yield losses under drought. Similar data for temperate climates are missing.
Tabea Selzer, Gereon Heller, Dietmar Horn, Thomas Hetterich, Jan Kessler, Jakob Santner   +5 more
wiley   +1 more source

Precision agriculture for water saving: The case of processing tomato and table grape

PLANTS, PEOPLE, PLANET, EarlyView.
Agriculture faces increasing pressure to produce high‐quality food while reducing water use under intensifying climate change and water scarcity. This study compared sensor‐based precision irrigation, drone monitoring, and near‐infrared spectroscopy with conventional farmer management in table grape and processing tomato production systems.
Giuseppe Ferrara, Alessandro Pesole, Rita De Marco, Sara Bisceglie, Giovanni Popeo, Simone Pascuzzi, Luigi Tedone   +6 more
wiley   +1 more source