Angewandte Chemie, EarlyView.Die Kontrolle biologischer Systeme mit organischen Chromophoren hat sich zu einer vielversprechenden Strategie entwickelt und findet Anwendung von der chemischen Biologie bis hin zur Medizin. Die Komplexität von In‐vivo‐Systemen lässt sich jedoch nicht mit nur einer einzigen Lichtwellenlänge adäquat abbilden.
Nadja A. Simeth
wiley +1 more source
A Crystalline and Thermally Stable Selenocysteine Selenenic Acid
Angewandte Chemie, EarlyView.The long‐sought catalytic intermediate of selenoproteins, selenocysteine selenenic acid (Sec–SeOH), is isolated for the first time at ambient temperature. A bioinspired selenopeptide sequence encapsulated within a protective molecular cradle and an oxidant‐free route from selenenyl iodide (Sec–SeI) enable the isolation of Sec–SeOH. Contrary to the long‐
Ryosuke Masuda, Satoru Kuwano, Kei Goto
wiley +2 more sources
Targeting GSTZ1 Sensitizes KRASG12C-Mutant Lung Cancer Cells by Overcoming Glutathione and Glycolysis Pathway Rewiring. [PDF]
Cancer Res CommunLiao Y +7 more
europepmc +1 more source
Chelator‐Free Radiometal Labeling Inside Engineered Affibodies
Angewandte Chemie, EarlyView.Affibodies are compact and robust three‑helix binders used in imaging and therapy. Engineering a triple‑cysteine motif into their core enables chelator‑free binding of important radiometals, like Bi(III), Pb(II), In(III), and Ga(III) with rapid uptake and exceptional stability.
Lani J. Davies +6 more
wiley +2 more sources
Effects of thymol and eugenol supplementation on reproductive performance, egg quality, and offspring health in broiler breeders. [PDF]
Poult SciSun H +5 more
europepmc +1 more source
Generalized Analysis of Electrophilic Small Molecules
Angewandte Chemie, EarlyView.Generalized fragmentation patterns stand to unlock the utility of tandem‐mass spectrometry for chemical reaction analysis but are bottlenecked by time consuming method development. Here were show how we can analyze most electrophilic small molecules the same way by their conjugation with a simple MS/MS encoded chemical probe.
Uma Neelakantan +9 more
wiley +2 more sources
2‐Azaazulenium Hemicyanine Dyes for NIR‐II Multimodal Imaging and Combined Phototherapy
Angewandte Chemie, EarlyView.A strategically engineered class of 2‐azaazulenium hemicyanines is developed, featuring bright fluorescence in the second near‐infrared (NIR‐II) window and multifunctional performance. SWJT‐OCH3 shows type I/II reactive oxygen species (ROS) generation and excellent photothermal activity.
Min Peng +8 more
wiley +2 more sources
Engineered CRISPR/Cas12a2 Nanoprobe Imaging in Living Cells for Precise Tumor Diagnosis. [PDF]
Small MethodsLi J +12 more
europepmc +1 more source
A Single Polyoxometalate Nanozyme for Cross-Reactive Thiol Array Sensing via pKa-Driven and Enrichment-Synergistic Strategy. [PDF]
Sensors (Basel)Sun B +6 more
europepmc +1 more source