Results 321 to 330 of about 374,227 (387)

Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development

The FEBS Journal, EarlyView.
Three skeletal muscle diseases are linked to HMGCR, a key enzyme in cholesterol synthesis. These diseases include a muscular dystrophy associated with pathogenic variants in the HMGCR gene, statin‐associated myopathy, and autoimmune anti‐HMGCR myopathy.
Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner, Gloriana Campos, Sree Venigalla, Elicia A. Estrella, Partha S. Ghosh, Audrey L. Daugherty, Seth A. Stafki, Louis M. Kunkel, A. Reghan Foley, Sandra Donkervoort, Carsten G. Bönnemann, Laura Toledo‐Bravo de Laguna, Andres Nascimento, Daniel Natera‐de Benito, Isabelle Draper, Christine C. Bruels, Christina A. Pacak, Peter B. Kang   +20 more
wiley   +1 more source

Molecular Insight into Amyloid Fibril-Templated Aggregation of Biomarkers. [PDF]

ACS Chem Neurosci
Zou R, Ågren H.
europepmc   +1 more source

Phosphatidic acid induces cytoskeletal rearrangements through the Src‐FAK‐RhoA/ROCK signaling pathway during decidualization

The FEBS Journal, EarlyView.
Decidualization is the process by which human endometrial stromal cells undergo morphological and functional changes to prepare the uterus for embryo implantation and support pregnancy. Our study identifies the phosphatidic acid‐Src‐FAK‐RhoA/ROCK signaling pathway as a critical regulator of the cytoskeletal alterations required for this transformation.
Hyeon‐Jeong Jun, So Young Lee, Shin‐Young Park, Joong Sub Choi, Mee‐Sup Yoon, Joong‐Soo Han   +5 more
wiley   +1 more source

Daraxonrasib, a pan-RAS inhibitor, selectively inhibits osteosarcomas with activated KRAS by halting AKT signaling and matrix metalloprotease activity. [PDF]

PLoS One
Jung O, Soto A, Wolfe AL, Mahajan SS.
europepmc   +1 more source

In vivo and in silico models of Drosophila for Parkinson's disease

The FEBS Journal, EarlyView.
In vivo and in silico models of Drosophila offer valuable advantages in the generation, analysis, and interpretation of complex biological data, thereby significantly advancing our understanding of Parkinson's disease. Molecular‐level measurements and phenotypic data from Drosophila are extensively utilised in metabolic network modeling and artificial ...
Müberra Fatma Cesur, Rachel Strazdins, Souvarish Sarkar, Tunahan Çakır   +3 more
wiley   +1 more source

Quantifying small GTPase activation status using a novel fluorescence HPLC-based assay. [PDF]

J Biol Chem
Araki M, Kasuya Y, Yoshimoto K, Katada T, Kontani K.   +4 more
europepmc   +1 more source

Gαs‐specific structural elements attenuate interactions with regulator of G protein signaling (RGS) proteins

The FEBS Journal, EarlyView.
Heterotrimeric (αβγ) G proteins are usually inactivated by regulators of G protein signaling (RGS) proteins, but Gαs is an exception. Comparative structural analysis identified unique Gαs structural elements that may interfere with RGS binding. Mutagenesis and biochemical assays showed that three residues in the Gαs GTPase domain are both necessary and
Sabreen Higazy‐Mreih, Meirav Avital‐Shacham, Christian LeGouill, Michel Bouvier, Mickey Kosloff   +4 more
wiley   +1 more source

A classical anti-autophagic viral protein reshapes mitochondria for immune evasion. [PDF]

Autophagy
Zhu Q, Liang C.
europepmc   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source