Results 1 to 10 of about 1,156 (76)

Cyclic peptide inhibitors function as molecular glues to stabilize Gq/11 heterotrimers. [PDF]

Proc Natl Acad Sci U S A
Mühle J, Alenfelder J, Rodrigues MJ, Jürgenliemke L, Guixà-González R, Grätz L, Andres F, Bacchin A, Hennig M, Schihada H, Crüsemann M, König GM, Schertler G, Kostenis E, Deupi X.   +14 more
europepmc   +1 more source

The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release. [PDF]

Mol Pharmacol
Issa NT, Shen T, Vizurraga A, Pronin A, Henry T, Wang Q, Kwarcinski FE, Schürer S, Badiavas E, Tall GG, Slepak VZ.   +10 more
europepmc   +1 more source

Non-canonical G_q activation by orexin receptor type 2 and lemborexant observed in microsecond molecular dynamics simulations. [PDF]

Sci Rep
Dragan P, Gratio V, Voisin T, Couvineau A, Latek D.   +4 more
europepmc   +1 more source

Structure of the G_q-coupled adhesion receptor ADGRL4. [PDF]

Nat Commun
Chen Q, Gusach A, Diamante A, Patel JC, Edwards PC, Tate CG, Favara DM.   +6 more
europepmc   +1 more source

Insights into G-protein coupling preference from cryo-EM structures of G_q-bound PTH1R. [PDF]

Nat Chem Biol
Sano FK, Shimizume K, Kobayashi K, Awazu T, Kawakami K, Akasaka H, Kobayashi TA, Tanaka T, Okamoto HH, Hirano H, Kusakizako T, Shihoya W, Kise Y, Itoh Y, Ishitani R, Okada Y, Sako Y, Yanagawa M, Inoue A, Nureki O.   +19 more
europepmc   +1 more source

GNAQ inhibits tumorigenesis via the ARHGEF25-mediated RHOA pathway in NK/T-cell lymphoma. [PDF]

Cancer Biol Ther
Gao Y, Zhang Z, Song Y, Song W, Li H, Zhang L, Li Z, Zhang M.   +7 more
europepmc   +1 more source

An integrated mechanism of G_q regulation of PLCβ enzymes. [PDF]

Proc Natl Acad Sci U S A
Senarath K, Fisher IJ, Jang W, Lu S, Inoue A, Kostenis E, Lyon AM, Lambert NA.   +7 more
europepmc   +1 more source

Conformational Signatures of Preassembled and Active Complexes of 5-HT₇ with the G_s Protein. [PDF]

J Chem Inf Model
Zara Z, Nicoli A, He R, Kulik N, Reha D, Bondar A, Di Pizio A.   +6 more
europepmc   +1 more source

Segmental Congenital Vascular Anomaly With Atrophy, Ulceration and Scarring With Complications in Pregnancy. [PDF]

Australas J Dermatol
Halbert AR, Hall A, Poulton C.
europepmc   +1 more source

Allosteric mechanism in the distinctive coupling of G_q and G_s to the parathyroid hormone type 1 receptor. [PDF]

Proc Natl Acad Sci U S A
Zhang X, Lee JY, Pacheco J, Sutkeviciute I, Anitha AK, Liu H, Singh S, Ventura C, Savransky S, Khatri A, Zhang C, Bahar I, Vilardaga JP.   +12 more
europepmc   +1 more source