Results 11 to 20 of about 1,156 (76)

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

British Journal of Pharmacology, Volume 178, Issue S1, Page S313-S411, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Doris Koesling, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Michael Russwurm, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +32 more
wiley   +1 more source

Cell‐permeable high‐affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors

British Journal of Pharmacology, Volume 177, Issue 8, Page 1898-1916, April 2020., 2020
Background and Purpose G proteins are intracellular switches that transduce and amplify extracellular signals from GPCRs. The Gq protein subtypes, which are coupled to PLC activation, can act as oncogenes, and their expression was reported to be up‐regulated in cancer and inflammatory diseases.
Markus Kuschak, Vigneshwaran Namasivayam, Muhammad Rafehi, Jan H. Voss, Jaspal Garg, Jonathan G. Schlegel, Aliaa Abdelrahman, Stefan Kehraus, Raphael Reher, Jim Küppers, Katharina Sylvester, Sonja Hinz, Michaela Matthey, Daniela Wenzel, Bernd K. Fleischmann, Alexander Pfeifer, Asuka Inoue, Michael Gütschow, Gabriele M. König, Christa E. Müller   +19 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

British Journal of Pharmacology, Volume 176, Issue S1, Page S297-S396, December 2019., 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators, Annie Beuve, Detlev Boison, Peter Brouckaert, John C Burnett, Kathryn Burns, Carmen Dessauer, Andreas Friebe, John Garthwaite, Jürg Gertsch, Nuala Helsby, Angelo A Izzo, Doris Koesling, Michaela Kuhn, Rennolds Ostrom, Andreas Papapetropoulos, Lincoln R Potter, Nigel J Pyne, Susan Pyne, Michael Russwurm, Harald HHW Schmidt, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts   +39 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes

British Journal of Pharmacology, Volume 174, Issue S1, Page S272-S359, December 2017., 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand ...
Stephen PH Alexander, Doriano Fabbro, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators   +11 more
wiley   +1 more source

Gq‐Coupled Receptors in Autoimmunity

Journal of Immunology Research, Volume 2016, Issue 1, 2016., 2016
Heterotrimeric G proteins can be divided into Gi, Gs, Gq/11, and G12/13 subfamilies according to their α subunits. The main function of G proteins is transducing signals from G protein coupled receptors (GPCRs), a family of seven transmembrane receptors.
Lu Zhang, Guixiu Shi, Xiao-Feng Yang
wiley   +1 more source

Gαq-Stimulated Gene Expression Is Insensitive to Bromo Extra Terminal Domain Inhibitors in HEK 293 Cells. [PDF]

Int J Mol Sci
Jain A, Pagé V, Devost D, Pétrin D, Hébert TE, Tanny JC.   +5 more
europepmc   +1 more source

An activating calcium-sensing receptor variant with biased signaling reveals a critical residue for Gα11 coupling. [PDF]

J Bone Miner Res
Benson MR, Wyatt RA, Levine MA, Gorvin CM.   +3 more
europepmc   +1 more source

An endothelial specific mouse model for the capillary malformation mutation Gnaq p.R183Q. [PDF]

Angiogenesis
Smits P, Marrs L, Cheng YS, Ad M, Nasim S, Zurakowski D, Bischoff J, Greene AK.   +7 more
europepmc   +1 more source

Pharmacological Gq targeting prevents asthmatic airway remodeling. [PDF]

Mol Ther
Dietrich JM, Matthey M, Simon A, Seidinger A, Koziol-White C, Panettieri RA, Fleischmann BK, Wenzel D.   +7 more
europepmc   +1 more source