Results 41 to 50 of about 1,156 (76)

Calcineurin-NFAT-DSCR1.4 signaling as druggable axis in Gαq-R183Q-driven capillary malformations. [PDF]

Angiogenesis
Xu T, Janssen V, Reinhard NR, Sobrevals-Alcaraz P, van Es RM, de Haan A, de Swart J, Wehrens M, de Kraker H, Wolkerstorfer A, van der Horst CMAM, Vos HR, Huveneers S.   +12 more
europepmc   +1 more source

Agonist-selective activation of individual G-proteins by muscarinic receptors. [PDF]

Sci Rep
Nelic D, Chetverikov N, Hochmalová M, Diaz C, Doležal V, Boulos J, Jakubík J, Martemyanov K, Janoušková-Randáková A.   +8 more
europepmc   +1 more source

The guanine nucleotide exchange factor Ric-8A regulates the sensitivity of constitutively active Gαq to the inhibitor YM-254890. [PDF]

J Biol Chem
Dwyer MB, Luo J, Todd TD, Blumer KJ, Tall GG, Wedegaertner PB.   +5 more
europepmc   +1 more source

A molecular mechanism to diversify Ca²⁺ signaling downstream of Gs protein-coupled receptors. [PDF]

Nat Commun
Brands J, Bravo S, Jürgenliemke L, Grätz L, Schihada H, Frechen F, Alenfelder J, Pfeil C, Ohse PG, Hiratsuka S, Kawakami K, Schmacke LC, Heycke N, Inoue A, König G, Pfeifer A, Wachten D, Schulte G, Steinmetzer T, Watts VJ, Gomeza J, Simon K, Kostenis E.   +22 more
europepmc   +1 more source

Allosteric modulation and biased signalling at free fatty acid receptor 2. [PDF]

Nature
Zhang X, Guseinov AA, Jenkins L, Valentini A, Marsango S, Schultz-Knudsen K, Ulven T, Rexen Ulven E, Tikhonova IG, Milligan G, Zhang C.   +10 more
europepmc   +1 more source

Diverse pathways in GPCR-mediated activation of Ca²⁺ mobilization in HEK293 cells. [PDF]

J Biol Chem
De Pascali F, Inoue A, Benovic JL.
europepmc   +1 more source

G Protein Selectivity in Dopamine Receptors is Determined before GDP Release. [PDF]

Biochemistry
Tawfeeq C, Hilibrand AS, Smith JS, Portillo J, Kruse AC, Abrol R.   +5 more
europepmc   +1 more source

Active state structures of a bistable visual opsin bound to G proteins. [PDF]

Nat Commun
Tejero O, Pamula F, Koyanagi M, Nagata T, Afanasyev P, Das I, Deupi X, Sheves M, Terakita A, Schertler GFX, Rodrigues MJ, Tsai CJ.   +11 more
europepmc   +1 more source

Psychedelic compounds directly excite 5-HT_2A layer V medial prefrontal cortex neurons through 5-HT_2A Gq activation. [PDF]

Transl Psychiatry
Schmitz GP, Chiu YT, Foglesong ML, Magee SN, MacKinnon M, König GM, Kostenis E, Hsu LM, Shih YI, Roth BL, Herman MA.   +10 more
europepmc   +1 more source

Structural response of G protein binding to the cyclodepsipeptide inhibitor FR900359 probed by NMR spectroscopy. [PDF]

Chem Sci
Bonifer C, Hanke W, Mühle J, Löhr F, Becker-Baldus J, Nagel J, Schertler GFX, Müller CE, König GM, Hilger D, Glaubitz C.   +10 more
europepmc   +1 more source