Results 101 to 110 of about 140,512 (290)

Activity of 1,3-β-D-Glucan Synthase Requires the GTP-binding Protein Rho1 [PDF]

, 1996
Paul Mazur, Walter F. Baginsky
openalex   +1 more source

Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214‐9, on Mitochondrial Fragmentation and Lytic Cell Death

Cytoskeleton, EarlyView.
ABSTRACT Septins are conserved GTP‐binding proteins that play key roles in cell division, mitochondrial dynamics and immune responses. Despite their importance to human health, pharmacological compounds to modify septins remain limited. Forchlorfenuron (FCF) was the first small molecule identified to modify septins, disrupting their organisation and ...
Dominik Brokatzky, Rajdeep Das, Hannah Painter, Rakesh K. Singh, Serge Mostowy   +4 more
wiley   +1 more source

Protein Secretion and GTP-binding Proteins.

Seibutsu Butsuri, 1991
GTP-binding proteins are involved in a wide variety of cellular functions. One of the most recent findings is the implication of many GTP-binding proteins in the pathway of protein secretion. In the eukaryotic secretory pathway, proteins have to be sorted from each other at many steps, including the signal recognition and translocation across the ...
openaire   +2 more sources

Signal transduction through the GTP-binding proteins Rac and Rho [PDF]

, 1994
Anne J. Ridley
openalex   +1 more source

Development and Characterization of a Noncovalent Stimulator of Interferon Genes Proteolysis‐Targeting Chimeras

ChemMedChem, EarlyView.
The design, synthesis, and initial biological evaluation of noncovalent stimulator of interferon genes degraders are presented. The lead from this series, BH690L, exhibits an effective concentration for half‐maximal degradation (DC50) of 11.3 nM and a maximum level of degradation (Dmax) of 0.67.
Bo Hu, Adam S. Duerfeldt
wiley   +1 more source

Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug‐resistant epilepsy: From operating room to wet lab

Epilepsia Open, EarlyView.
Abstract Objective We have established a comprehensive sample handling protocol designed for the multiscale assessment of epileptogenic tissue. This protocol aims to identify novel therapeutic targets and enhance the diagnosis and stratification of patients with drug‐resistant epilepsy, thereby optimizing their treatment with anti‐seizure medications ...
Jenni Kyyriäinen, Adriana Della Pietra, Mastaneh Torkamani‐Azar, Mireia Gómez‐Budia, Polina Abushik, Nataliia Novosolova, Henri Eronen, Omar Narvaez, Ekaterina Paasonen, Vera Lezhneva, Anssi Pelkonen, Liudmila Saveleva, Antti Huotarinen, Ilya Belevich, Eija Jokitalo, Kuopio Epilepsy Center Epilepsy Surgery Group, Leena Jutila, Tuomas Rauramaa, Arto Immonen, Ville Leinonen, Jussi Tohka, Olli Gröhn, Reetta Kälviäinen, Tarja Malm, Alejandra Sierra   +24 more
wiley   +1 more source

A cDNA Encoding a New GTP-Binding Protein of the ADP-Ribosylation Factor Family from Arabidopsis [PDF]

, 1994
Matthieu Lebas
openalex   +1 more source

rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.

, 1990
Gabriele Fischer von Mollard, Gregory A. Mignery, Marion Baumert, M S Perin, T J Hanson, P.M. Burger, Reinhard Jahn, Thomas C. Südhof   +7 more
openalex   +1 more source

Detection of Small GTP Binding Proteins Showing GTPase and GTP/ATP Binding Activities in the Ovary of the American Cockroach, Periplaneta Americana, during Oogenesis [PDF]

, 2014
Mohamed Elmogy
openalex   +1 more source

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang, Robert A. Hauser, Lorraine V. Kalia, Bonnie Hersh, Zdenek Berger, Roy Llorens Arenas, Coro Paisan‐Ruiz, Kyle Fraser, Danna Jennings, Jillian H. Kluss, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, J. Timothy Greenamyre   +12 more
wiley   +1 more source