Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations [PDF]
, 2007 Background Folate synthesis and salvage pathways are relatively well known from classical biochemistry and genetics but they have not been subjected to comparative genomic analysis.
de Crécy-Lagard, Valérie +4 more
core +3 more sources
Oncogene, 2016 Type 2 transglutaminase (TG2) is an important cancer stem cell survival protein that exists in open and closed conformations. The major intracellular form is the closed conformation that functions as a GTP-binding GTPase and is required for cancer stem ...
C. Kerr +11 more
semanticscholar +1 more source
Les atrophies optiques héréditaires [PDF]
, 2010 IntroductionLes atrophies optiques héréditaires forment un groupe hétérogène de maladies responsables d’une dégénérescence des cellules ganglionnaires de la rétine avec une expression phénotypique variable, allant de formes asymptomatiques jusqu’à des ...
C. Scherer +8 more
core +2 more sources
GDP-to-GTP exchange on the microtubule end can contribute to the frequency of catastrophe
bioRxiv, 2016 Microtubules are dynamic polymers of αβ-tubulin that have essential roles in chromosome segregation and organizing the cytoplasm. Catastrophe – the switch from growing to shrinking – occurs when a microtubule loses its stabilizing GTP cap.
Felipe-Andrés Piedra +6 more
semanticscholar +1 more source
Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing [PDF]
, 2013 BACKGROUND: The major role of enzymatic toxins that target nucleic acids in biological conflicts at all levels has become increasingly apparent thanks in large part to the advances of comparative genomics.
A Maxwell Burroughs +4 more
core +1 more source
The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates [PDF]
, 2002 BACKGROUND: The CyaB protein from Aeromonas hydrophila has been shown to possess adenylyl cyclase activity. While orthologs of this enzyme have been found in some bacteria and archaea, it shows no detectable relationship to the classical nucleotide ...
Aravind, L, Iyer, Lakshminarayan M
core +3 more sources
Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G
Science Advances, 2015 Cryo-EM study reveals key molecular structural features for activation of guanosine triphosphate cleavage by EF-G during translocation. During protein synthesis, elongation of the polypeptide chain by each amino acid is followed by a translocation step ...
Wen Li +5 more
semanticscholar +1 more source
De la levure aux maladies neurodégénératives : Dix ans d’exploration des pathologies de la dynamique mitochondriale [PDF]
, 2010 Ten years ago, OPA1 was identified as the major gene responsible for hereditary optic nerve degeneration, evidencing the first defect in mitochondrial network dynamics as the princeps pathophysiological mechanism in a mitochondriopathy.
A. Chevrollier +9 more
core +2 more sources
Development of a Novel Lysophosphatidic Acid Activity Probe to Identify and Characterize New Protein Targets [PDF]
, 2009 Lipids are categorized according to their biological function. Phospholipids, glycolipids, and cholesterol are bulk membrane lipids that offer structure and support to the cells and organelle membranes.
Cuthriell, Leah M.
core +1 more source
BIOLOGICAL FUNCTIONS OF THE NOVEL LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR, LPA\u3csub\u3e4\u3c/sub\u3e/p2y9/GPR23 [PDF]
, 2008 Lysophosphatidic acid (LPA), a naturally occurring phospholipid present in serum and malignant effusions, elicits diverse biological functions through binding and activating specific cell surface G-protein coupled receptors.
Lee, Peilun
core +1 more source