Nucleotide analogs and molecular modeling studies reveal key interactions involved in substrate recognition by the yeast RNA triphosphatase [PDF]
RNA triphosphatases (RTPases) are involved in the addition of the distinctive cap structure found at the 5′ ends of eukaryotic mRNAs. Fungi, protozoa and some DNA viruses possess an RTPase that belongs to the triphosphate tunnel metalloenzyme family of ...
Benarroch +17 more
core +2 more sources
The diguanylate cyclase AdrA regulates flagellar biosynthesis in Pseudomonas fluorescens F113 through SadB [PDF]
, 2019 Flagellum mediated motility is an essential trait for rhizosphere colonization by pseudomonads. Flagella synthesis is a complex and energetically expensive process that is tightly regulated.
Arrebola, Eva +8 more
core +1 more source
Borrelia burgdorferi bb0426 encodes a 2′-deoxyribosyltransferase that plays a central role in purine salvage [PDF]
Borrelia burgdorferi is an obligate parasite with a limited genome that severely narrows its metabolic and biosynthetic capabilities. Thus survival of this spirochaete in an arthropod vector and mammalian host requires that it can scavenge amino acids ...
Abbott +34 more
core +2 more sources
Studies on OX1 Orexin Receptor Coupling to Arachidonic Acid and Endocannabinoid Signaling [PDF]
, 2012 Orexin A and orexin B are hypothalamic neuropeptides secreted by a relatively small group of neurons located within the hypothalamus. Orexins bind and activate two G-protein-coupled receptors termed OX1 orexin receptor and OX2 orexin receptor.
Turunen, Pauli
core
OPA1 links human mitochondrial genome maintenance to mtDNA replication and distribution [PDF]
, 2010 Eukaryotic cells harbor a small multiploid mitochondrial genome, organized in nucleoids spread within the mitochondrial network. Maintenance and distribution of mitochondrial DNA (mtDNA) are essential for energy metabolism, mitochondrial lineage in ...
A. Olichon +18 more
core +4 more sources
Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
Brain : a journal of neurology, 2014 Mutations in the gene encoding the dopamine-synthetic enzyme GTP cyclohydrolase-1 (GCH1) cause DOPA-responsive dystonia (DRD). Mencacci et al. demonstrate that GCH1 variants are associated with an increased risk of Parkinson's disease in both DRD ...
N. Mencacci +47 more
semanticscholar +1 more source
A 16.7 kb deletion in \u3ci\u3eSipa1l3\u3c/i\u3e is associated with juvenile cataract in mice [PDF]
, 2017 Congenital or juvenile cataract is a disease condition in which opacification of the lenses is present at birth or manifests early in life. It has been attributed to different monogenic factors with a high degree of heterogeneity and is often studied ...
Abebe, Marytza D. +9 more
core +1 more source
Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis [PDF]
SAMHD1 regulates cellular nucleotide homeostasis, controlling dNTP levels by catalysing their hydrolysis into 2’-deoxynucleosides and triphosphate. In differentiated CD4+ macrophage and resting T-cells SAMHD1 activity results in the inhibition of HIV-1 ...
Acton, Oliver J. +9 more
core +2 more sources
Biochemical Markers of Lymphocyte Maturation [PDF]
, 2020 KováfiÛ H., F. KováfiÛ, A. Fi‰erová, P. Zelníãková, E. Matalová: Biochemical Markers of Lymphocyte Maturation. Acta Vet Brno 2002, 71: 503-508. We studied maturation-associated changes of cell membrane Na + , K + -and Mg 2+ -ATPase activities and gamma ...
A Fi·erová +4 more
core
Bisphosphonate Modulates Cementoblast Behavior In Vitro [PDF]
, 2005 Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142297/1/jper1890 ...
Benford HL +16 more
core +1 more source