Results 41 to 50 of about 210,108 (236)

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

LCN2‐ACOD1 Signalling Affects the Post‐Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis

Cell Proliferation, EarlyView.
LCN2 mediates the suppression of C2C12 myoblast proliferation and myotube formation via erastin‐induced ferroptosis. Mechanistically, the LCN2‐ACOD1 axis regulates skeletal muscle growth via mitochondria‐associated ferroptosis, providing a theoretical basis for the prevention and therapy of muscle‐related diseases.
Xiaojing Hao, Hongwei Shi, Di Wu, Rui Liang, Tong Zhao, Wen Sun, Yue Wang, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Haidong Wang, Juan Wang   +12 more
wiley   +1 more source

The Emotional Valence Paradox in Social media: A Computational Linguistic Analysis of How Sentiment, Emotion, and Content Domain Predict Social Comparisons on Rednote

International Journal of Applied Linguistics, EarlyView.
ABSTRACT This computational linguistic study analyzes 8743 Rednote posts to examine how sentiment, emotion, and content domain collectively shape social comparison dynamics on social media. We identify four key findings: (1) an emotional gradient, where upward comparison content exhibits the highest sentiment scores and downward comparison the lowest; (
Michelle Mingyue Gu, Shuting Zhang, Yue Zhang, Hua Zhao, Jiapei Gu, Jincheng Ding, Xiaofei Lu, Chetwyn Che‐hin Chan   +7 more
wiley   +1 more source

Evaluating a Group‐Based Intervention Addressing Fear of Childbirth in Multiparous Pregnant Women: A Mixed Methods Feasibility Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To assess the feasibility and acceptability of a group‐based intervention for addressing fear of childbirth in multiparous women. Design Single‐arm non‐randomised feasibility trial with a convergent mixed methods design. Methods The intervention, conducted at a central maternity hospital and led by a psychiatric nurse and a midwife ...
Laura Sandström, Marja Kaunonen, Heini Huhtala, Anna Liisa Aho   +3 more
wiley   +1 more source

Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine

Photochemistry and Photobiology, EarlyView.
6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes, Fernanda M. Prado, Helena C. Junqueira, Marisa H. G. Medeiros, Graziella E Ronsein, Jean Cadet, Paolo Di Mascio   +6 more
wiley   +1 more source

Protease‐mediated maturation of M‐PMV reverse transcriptase into a functional heterodimer

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Reverse transcriptase (RT) of retroviruses orchestrates viral replication, yet its structural diversity remains poorly understood. Well‐studied RTs, such as those from HIV‐1, murine leukemia virus, and avian myeloblastosis virus, were characterized decades ago, but less prominent retroviruses have escaped detailed analysis.
Marina Kapisheva, Petra Junková, Ondřej Vaněk, Zuzana Jalovcová, Ivana Křížová, Alžběta Dostálková, Michaela Rumlová   +6 more
wiley   +1 more source

Resistance mechanisms in collard green genotypes to Plutella xylostella: role of physical and morphological traits

Pest Management Science, Volume 82, Issue 2, Page 1974-1984, February 2026.
Resistance to Plutella xylostella in collard greens is mediated by antixenosis and antibiosis, associated with traits such as leaf wax, hardness, and color. Genotypes showed strong resistance potential, supporting their use in breeding and integrated pest management strategies. Abstract BACKGROUND The diamondback moth, Plutella xylostella (Lepidoptera:
Aline Marques Pinheiro, Edson Luiz Lopes Baldin, Vinicius Fernandes Canassa, Alisson da Silva Santana, Thais Lohaine Braga dos Santos, André Luiz Lourenção, Carlos Gilberto Raetano   +6 more
wiley   +1 more source

Uncovering the signaling pathway behind extracellular guanine-induced activation of NO System: New perspectives in memory-related disorders [PDF]

, 2018
Mounting evidence suggests that the guanine-based purines stand out as key player in cell metabolism and in several models of neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases.
Belluardo, Natale, Buccella, Silvana, Caciagli, Francesco, Carluccio, Marzia, Ciccarelli, Renata, Condorelli, Daniele F., Di Iorio, Patrizia, Frinchi, Monica, Giuliani, Patricia, Mud\uf2, Giuseppa, Serio, Rosa Maria, Zuccarini, Mariachiara   +11 more
core   +1 more source

Gua Kidang, Hunian Gua Kala Holosen di Das Solo

KALPATARU, 2015
Gua Kidang merupakan hunian manusia prasejarah yang diteliti Balai Arkeologi Yogyakarta sejak tahun 2005 dan masih berlanjut sampai sekarang. Berdasarkan survey permukaan di seluruh kawasan karst Blora, Gua Kidang adalah satu-satunya gua yang layak huni.
Indah Asikin Nurani, Agus Tri Hascaryo
openaire   +2 more sources

Diagnóstico da pesca artesanal na usina hidrelétrica de Machadinho, alto Rio Uruguai - Brasil

Boletim do Instituto de Pesca, 2018
O reservatório de Machadinho, formado no ano de 2001, está localizado na região do alto rio Uruguai. Procurando diagnosticar a pesca neste reservatório, assim como a composição ictiofauní­­stica ao longo dos anos após o represamento foram aplicados ...
Gianfrancisco SCHORK, Samara HERMES-SILVA, Luis Fernando BEUX, Evoy ZANIBONI-FILHO, Alex Pires de Oliveira NUÑER   +4 more
doaj