Results 121 to 130 of about 379,799 (309)

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Dental caries is negatively correlated with body mass index among 7-9 years old children in Guangzhou, China

, 2016
Background Evidence linking caries in primary dentition and children’s anthropometric measures is contradictory. We aimed to evaluate the prevalence of primary dental caries and its relationship with body mass index (BMI) among 7-9 years old school ...
Mai, Jin-cheng, Yang, Wen-han, Zhang, Zhe-qing, Liang, Jing-jing, Jin Jing, Jing, Jin, Zhe-qing Zhang, Chen, Ya-jun, Jin-cheng Mai, Wen-han Yang, Jun Ma, Ma, Jun, Ya-jun Chen, Jing-jing Liang   +13 more
core   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Preliminary study of organic pollutants in air of Guangzhou, Hong Kong, and Macao

, 1996
Preliminary investigations were carried out on the extractable organic matter in aerosols and volatile organic compounds (VOCs) in ambient air of Guangzhou, Hongkong and Macao. Based on the types and abundances of biomarkers in the aliphatic and aromatic
Wang XM, Fu JM, Min YS, Wang ZS, Peng P, Sheng GY, Chan LY, Chen Y, Lee SC   +8 more
core  

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Pro- and Contra-Coalition: Governing the Rise and Fall of Creative Industrial Parks in China

Urban Planning
A great number of creative industrial parks (CIPs) have emerged in the past two decades in China as a critical and popular approach to the adaptive reuse of abandoned industrial land in cities. However, a few vibrant CIPs have been closed in the past few
Xueying Chen, Li Fan, Zhikui Cao
doaj   +1 more source

A Multiple Linear Regression Model for Estimating Global Solar Radiation in Guangzhou, China

, 2013
Empirical modeling is an essential and economical tool for estimating solar radiation. Based on statistical error tests, a model with relative sunshine duration, difference between average maximum and minimum air temperatures, relative humidity, and ...
Li, H. S., Bu, X. B., Lian, Y. W., Ma, W. B., Wang, X. L.   +4 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

The short-term effect of ambient ozone on mortality is modified by temperature in Guangzhou, China

, 2013
Effects of ozone on mortality have been widely assessed in developed countries but rarely in developing countries, and the effects of season and temperature on these associations remain unclear. The present study aimed to explore the modifying effects of
Ma, Wen Jun, Chu, Cordia, Li, Tian Tian, Xie, Hui Yan, Liu, Zhao Rong, Luo, Yuan, Xu, Xiao Jun, Rutherford, Shannon, Liu, Tao, Xu, Yan Jun, Lao, Xiang Qian, Zhu, Qi, Zhang, Yong Hui   +12 more
core   +1 more source

Frustrated Lewis Pairs and Metallic Ni Synergistically Enabled Low‐Temperature Hydrogenolysis of Lignin Models

Advanced Science, EarlyView.
Nickel–aluminum composite oxide (NiAlOx‐300) derived from NiAl layered double hydroxide showed high activity for hydrogenolysis of various lignin models. Especially, hydrogenolysis of benzyl phenyl ether could be efficiently proceeded at 20°C and 1 MPa H2.
Jinpeng Liang, Ziyi Ma, Zhaoxi Cai, Kongqian Liang, Chenglei Xiao, Sitong Chen, Na Wang, Zhimin Xue, Chao Xie, Jinliang Song   +9 more
wiley   +1 more source