Cyclic Dimeric Guanosine Monophosphate: Activation and Inhibition of Innate Immune Response. [PDF]
J Innate Immun, 2019 Cyclic dimeric guanosine monophosphate (c-di-GMP) is a universally conserved second messenger that contributes to the pathogenicity of numerous bacterial species.
Cui T, Cang H, Yang B, He ZG.
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The cyclic guanosine monophosphate synthase-stimulator of interferon genes pathway as a potential target for tumor immunotherapy [PDF]
Frontiers in Immunology, 2023 Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self-DNA in the cytoplasm. Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein
Rui Chen +4 more
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Guanosine monophosphate reductase 1 is a potential therapeutic target for Alzheimer's disease. [PDF]
Sci Rep, 2018 Alzheimer’s disease (AD) is a severe neurodegenerative disorder for which identification of differentially expressed genes is one way to find new therapeutic targets. Here, we conducted analysis to identify age-independent, AD-specific genes.
Liu H, Luo K, Luo D.
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Polygonatum sibiricum (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphate‐protein kinase G signaling in diabetic mice [PDF]
Journal of Diabetes InvestigationAims/Introduction Diabetic cardiomyopathy (DCM) is a prevalent condition among individuals with diabetes, and is associated with a high mortality rate.
Shengping Lei +5 more
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Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation.
Wendy Ying +15 more
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Ag(+)-mediated assembly of 5'-guanosine monophosphate. [PDF]
The Journal of Physical Chemistry B, 2010 Polymorphic forms of nucleic acids provide platforms for new nanomaterials, and transition metal cations give access to alternative arrangements of nucleobases by coordinating with electron-rich functional groups.
Kristine M Loo +7 more
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Chemo- and Thermosensory Responsiveness of Grueneberg Ganglion Neurons Relies on Cyclic Guanosine Monophosphate Signaling Elements [PDF]
Neurosignals, 2011 Neurons of the Grueneberg ganglion (GG) in the anterior nasal region of mouse pups respond to cool temperatures and to a small set of odorants. While the thermosensory reactivity appears to be mediated by elements of a cyclic guanosine monophosphate ...
Katharina Mamasuew +6 more
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Cell Reports, 2013 Melanoma is one of the most aggressive types of human cancers, and the mechanisms underlying melanoma invasive phenotype are not completely understood. Here, we report that expression of guanosine monophosphate reductase (GMPR), an enzyme involved in de ...
Joseph A. Wawrzyniak +19 more
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Current Modulation of Guanylate Cyclase Pathway Activity—Mechanism and Clinical Implications
Molecules, 2021 For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme; however, in the last few years, in light of preclinical and clinical trials, it became an interesting target for pharmacological intervention.
Grzegorz Grześk, Alicja Nowaczyk
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