Results 11 to 20 of about 165,669 (302)

Polygonatum sibiricum (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphate‐protein kinase G signaling in diabetic mice [PDF]

Journal of Diabetes Investigation
Aims/Introduction Diabetic cardiomyopathy (DCM) is a prevalent condition among individuals with diabetes, and is associated with a high mortality rate.
Shengping Lei, Xin Lu, Lei Yan, Tian Liu, Yan Niu, Jun Yu   +5 more
doaj   +2 more sources

Supramolecular transcription of guanosine monophosphate into mesostructured silica.

Angewandte Chemie, 2014
AbstractThere is large interest in replicating biological supramolecular structures in inorganic materials that are capable of mimicking biological properties. The use of 5‐guanosine monophosphate in the presence of Na+ and K+ ions as a supramolecular template for the synthesis of well‐ordered mesostructured materials is reported here.
Carlos J Bueno-Alejo, L. Villaescusa, A. Garcia‐Bennett   +2 more
semanticscholar   +5 more sources

Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation.
Wendy Ying, Di Zhao, Pamela Ouyang, Vinita Subramanya, Dhananjay Vaidya, Chiadi E. Ndumele, Eliseo Guallar, Kavita Sharma, Sanjiv J. Shah, David A. Kass, Ron C. Hoogeveen, Joao A. Lima, Susan R. Heckbert, Christopher R. deFilippi, Wendy S. Post, Erin D. Michos   +15 more
doaj   +2 more sources

A Purine Nucleotide Biosynthesis Enzyme Guanosine Monophosphate Reductase Is a Suppressor of Melanoma Invasion

Cell Reports, 2013
Melanoma is one of the most aggressive types of human cancers, and the mechanisms underlying melanoma invasive phenotype are not completely understood. Here, we report that expression of guanosine monophosphate reductase (GMPR), an enzyme involved in de ...
Joseph A. Wawrzyniak, Anna Bianchi-Smiraglia, Wiam Bshara, Sudha Mannava, Jeff Ackroyd, Archis Bagati, Angela R. Omilian, Michael Im, Natalia Fedtsova, Jeffrey C. Miecznikowski, Kalyana C. Moparthy, Shoshanna N. Zucker, Qianqian Zhu, Nadezhda I. Kozlova, Albert E. Berman, Keith S. Hoek, Andrei V. Gudkov, Donna S. Shewach, Carl D. Morrison, Mikhail A. Nikiforov   +19 more
doaj   +2 more sources

Beta Testing New Roles of Cyclic Guanosine Monophosphate in Cardiac Myocyte Contractility [PDF]

JACC: Basic to Translational Science
Robert M. Blanton, MA, MD
doaj   +2 more sources

Current Modulation of Guanylate Cyclase Pathway Activity—Mechanism and Clinical Implications

Molecules, 2021
For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme; however, in the last few years, in light of preclinical and clinical trials, it became an interesting target for pharmacological intervention.
Grzegorz Grześk, Alicja Nowaczyk
doaj   +1 more source

Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes

JACC: Basic to Translational Science, 2023
Summary: Reduced nitric oxide (NO) bioactivity in red blood cells (RBCs) is critical for augmented myocardial ischemia-reperfusion injury in type 2 diabetes.
Tong Jiao, MD, PhD, Aida Collado, PhD, Ali Mahdi, MD, PhD, John Tengbom, MD, Yahor Tratsiakovich, MD, PhD, G. Todd Milne, PhD, Michael Alvarsson, MD, PhD, Jon O. Lundberg, MD, PhD, Zhichao Zhou, MD, PhD, Jiangning Yang, MD, PhD, John Pernow, MD, PhD   +10 more
doaj   +1 more source

Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth

Journal of Pathology, 2021
Glutamine is a critical nutrient in cancer; however, its contribution to purine metabolism in prostate cancer has not previously been determined. Guanosine monophosphate synthetase (GMPS) acts in the de novo purine biosynthesis pathway, utilizing a ...
Qian Wang, Y. Guan, Sarah E. Hancock, K. Wahi, M. van Geldermalsen, Blake K. Zhang, A. Pang, R. Nagarajah, B. Mak, Natasha Freidman, L. Horvath, N. Turner, J. Holst   +12 more
semanticscholar   +1 more source

Hydrophilic interaction liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry for determination of nuclear and cytoplasmatic contents of nucleotides, nucleosides and their nucleobases in food yeasts

Talanta Open, 2021
Hydrophilic interaction liquid chromatography using a zwitterionic phase, coupled with high-resolution mass spectrometry based on quadrupole and time-of-flight mass analyser (HILIC-Q-TOF-MS) is applied for the determination of four nucleobases (adenine ...
Marta Pastor-Belda, Inmaculada Fernández-Caballero, Natalia Campillo, Natalia Arroyo-Manzanares, Manuel Hernández-Córdoba, Pilar Viñas   +5 more
doaj   +1 more source

Electrocatalytic Oxidation of Guanine, Guanosine, and Guanosine Monophosphate [PDF]

Biophysical Journal, 2007
The electrochemical behavior of guanine, guanosine, and guanosine monophosphate (GMP) at redox polymer film modified indium tin oxide electrodes is examined by voltammetry and redox titration. Utilizing the redox polymer-coated electrodes as indicator electrodes, a new method for measuring the oxidation potentials, based on monitoring their catalytic ...
Xie, H., Yang, D., Heller, A., Gao, Z.
openaire   +2 more sources