Results 131 to 140 of about 162,062 (330)

The dynamic structure of Rab35 is stabilized in the presence of GTP under physiological conditions

Biochemistry and Biophysics Reports, 2020
Rab proteins, a family of small guanosine triphosphatases, play key roles in intracellular membrane trafficking and the regulation of various cellular processes.
Takuya Murata, Yuka Unno, Mitsunori Fukuda, Naoko Utsunomiya-Tate   +3 more
doaj  

Post-Translational Modification and Subcellular Distribution of Rac1: An Update

Cells, 2018
Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell ...
Abdalla Abdrabou, Zhixiang Wang
doaj   +1 more source

Erythrocyte Inosine triphosphatase activity: A potential biomarker for adverse events during combination antiretroviral therapy for HIV [PDF]

, 2018
The purine analogues tenofovir and abacavir are precursors of potential substrates for the enzyme Inosine 5’-triphosphate pyrophosphohydrolase (ITPase).
Bakker, J.A. (Jaap), Bierau, J. (Jörgen), Bosch, B. (Bianca) van den, Hansen, B.E. (Bettina E.), Leers, J. (Joerg), Lowe, S. (S.), Paulussen, A.D.C. (Aimée), Peltenburg, N.C. (Nicole Chantal), Schippers, J.A. (Jolanda ), Verbon, A. (Annelies)   +9 more
core   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]

, 2017
Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P, Hodeib, Melissa, Karlan, Beth Y, Lunt, Sophia Y, Ogrodzinski, Martin P, Reue, Karen, Vergnes, Laurent   +6 more
core   +1 more source

Demonstration of a guanosine triphosphate-dependent enzymatic binding of aminoacyl-ribonucleic acid to Escherichia coli ribosomes.

Proceedings of the National Academy of Sciences of the United States of America, 1967
Multiple enzyme fractionS< have been shown to be required for the synthesis of polypeptides from aminoacyl-sRNA in both mammalian and microbial systems.1'6 In the reticulocyte system two enzyme fractions have been founid to be required for the ...
M. Ravel, Roger J. Williams
semanticscholar   +1 more source

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source

Increased neopterin concentration in patients with primary arterial hypertension

Journal of Medical Science, 2015
The data on the safety profile of anti-tumor necrosis factor (anti-TNF) therapy in real-life patients cohorts with in flammatory bowel disease (IBD) still are lacking.
Artur Cieślewicz, Katarzyna Korzeniowska, Paweł Bogdański, Anna Jabłecka   +3 more
doaj   +1 more source

Characterization of wheat oligo-tiller mutant ot2 and fine mapping of the mutant gene Taot2. [PDF]

Plant Genome
Abstract Tiller number is a crucial determinant of grain yield in wheat (Triticum aestivum L.), and identifying functional alleles can enhance our understanding of wheat tiller development. Here, we describe the ot2 wheat mutant, which exhibits a 91% reduction in tiller number compared to the wild type and displays inhibited tiller bud differentiation ...
Wang C, Bai J, Xiong H, Xie Y, Gu J, Zhao L, Li H, Ding Y, Guo X, Guo H, Liu L.   +10 more
europepmc   +2 more sources

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes. [PDF]

Chembiochem
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Décout JL, Maurel MC.
europepmc   +2 more sources