Effects of guanosine 5′‐[γ‐thio]triphosphate and thrombin on the phosphoinositide metabolism of electropermeabilized human platelets [PDF]
, 1988 Martine Culty +2 more
openalex +1 more source
Salvage enzymes in nucleotide biosynthesis [PDF]
, 2007 Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
core
Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells
Advanced Science, Volume 12, Issue 47, December 18, 2025.Brief 10 min bursts of high frequency (10 MHz) vibrational mechanostimulation to stem cells are shown to activate their epigenetic machinery to condition their differentiation down an osteogenic lineage within just 3 days, which is much earlier than that with other forms of mechanostimuli, and without requiring any biochemical additives. Abstract Cells
Lizebona A. Ambattu +3 more
wiley +1 more source
Stimulation of phosphoenolpyruvate carboxykinase (guanosine triphosphate) activity by low concentrations of circulating glucose in perfused rat liver [PDF]
, 1975 F. Moreno +4 more
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Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders
Advanced Science, Volume 12, Issue 47, December 18, 2025.This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin +8 more
wiley +1 more source
The Role and Therapeutic Potential of the cGAS‐STING Signaling Pathway in Alzheimer's Disease
Brain and Behavior, Volume 15, Issue 12, December 2025.This work reveals the relationship between the cGAS‐STING signaling pathway and the pathological mechanisms of Alzheimer's disease.The role of the cGAS‐STING signaling pathway in AD pathology. AD leads to the production of neutrophil extracellular traps (NETs), endoplasmic reticulum (ER) stress, and the release of mitochondrial DNA (mtDNA) and nuclear ...
Xue Li, Wei Gao, Qiuyan Ye, Honglin Li
wiley +1 more source
Human granulocyte colony-stimulating factor specifically binds to murine myeloblastic NFS-60 cells and activates their guanosine triphosphate binding proteins/adenylate cyclase system [PDF]
, 1989 Sachiko Matsuda +2 more
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Clinical Case Reports, Volume 13, Issue 12, December 2025.ABSTRACT This is the first report of trametinib‐nintedanib for a 57‐year‐old KRAS G12D‐mutated recurrent pancreatic ductal adenocarcinoma. He had transient remission (lower CA19‐9, stable lesions) but died of gastrointestinal bleeding, showing efficacy and bleeding risk.
Yufei Zhao +3 more
wiley +1 more source
Advances in the Gut‐Lung Axis and Bronchial Asthma: From Mechanisms to Therapeutic Potential
Clinical and Translational Allergy, Volume 15, Issue 12, December 2025.ABSTRACT Background Bronchial asthma (hereafter referred to as asthma) is a heterogeneous disease characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and reversible airflow limitation. Recent advancements in the “gut‐lung” axis concept have elucidated the intricate immunometabolic crosstalk between the gastrointestinal tract
Ting Zheng, Yi Huang, Hongmei Yao
wiley +1 more source