New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain
Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song +8 more
wiley +2 more sources
Molecular Dynamics Simulations of a Putative Novel Mechanism for UCP1‐Assisted FA Anion Transport
Acta Physiologica, Volume 241, Issue 7, July 2025.ABSTRACT Background Mitochondrial energy can be stored as ATP or released as heat by uncoupling protein 1 (UCP1) during non‐shivering thermogenesis in brown adipose tissue. UCP1, located in the inner mitochondrial membrane, reduces the proton gradient in the presence of long‐chain fatty acids (FA).
Sanja Vojvodić +3 more
wiley +1 more source
Derivatives of Guanosine Triphosphate with Ribose 2′‐Hydroxyl Substituents [PDF]
, 1976 Ernest Hamel
openalex +1 more source
British Journal of Pharmacology, Volume 182, Issue 14, Page 3320-3335, July 2025.Abstract Background and Purpose Whereas biased agonism on the 5‐HT2A receptor has been ascribed to hallucinogenic properties of psychedelics, no information about biased inverse agonism on this receptor is available. In schizophrenia, increased 5‐HT2A receptor constitutive activity has been suggested, highlighting the therapeutic relevance of inverse ...
Itziar Muneta‐Arrate +4 more
wiley +1 more source
A Comparison on the Coordination Tendency towards Cu2+ of the Base Moieties in Guanosine, Inosine and Adenosine 5′‐Triphosphates [PDF]
, 1974 Helmut Sigel +2 more
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Kinetic and Structural Analysis of the Mg2+ -binding Site of the Guanine Nucleotide-binding Protein p21 H-ras. [PDF]
, 1993 The coordination and binding of the Mg2+ ion in the nucleotide−binding site of p21 have been investigated using site−directed mutagenesis, kinetic methods, and phosphorous NMR.
Borasio, Gian Domenico +6 more
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ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Obesity Reviews, Volume 26, Issue 7, July 2025.Summary With the evolving landscape of diseases, heart failure with preserved ejection fraction (HFpEF) now encompasses more than half of all heart failure patients. This condition is clinically diverse, involving multiple organ systems and often occurring alongside the aging process.
Zhongwen Qi +6 more
wiley +1 more source
Evidence that insulin and guanosine triphosphate regulate dephosphorylation of the β-subunit of the insulin receptor in sarcolemma membranes isolated from skeletal muscle [PDF]
, 1986 Richard Horn +3 more
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A phased-addition strategy enhances the yield of RNAs obtained by in vitro transcription with modified transcriptional initiators [PDF]
, 2015 RNA is active in multiple biological processes, not only as an information carrier but in catalyzing reactions and regulating gene expression. To understand the basis for this versatility, it is critical to establish structure-function relationships in ...
Adib, Katie
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