Results 211 to 220 of about 178,961 (291)

Repurposing of the nucleoside analogs for influenza. [PDF]

Comput Struct Biotechnol J
Mee-Udorn P, Narkpuk J, Jaru-Ampornpan P, Hongeng S, Uengwetwanit T, Srimongkolpithak N.   +5 more
europepmc   +1 more source

Pleiotropic regulation of mitochondrial translational factors in governing proliferation, apoptosis and metastasis during cancer progression. [PDF]

World J Clin Oncol
Agarwal N, Sharma U, Shree A, Kumar RR, Gorain JK, Vishwas V, Jahan F, Singh A, Palanichamy JK, Pushpam D, Bakhshi R, Chopra A, Sahoo RK, Batra A, Sharawat SK, Bakhshi S.   +15 more
europepmc   +1 more source

A Rare Intra-Atrial Cyst of Vascular Origin: Genetic Insights From a Case. [PDF]

JACC Case Rep
Wang T, Zhang Y, Qiao S, Han Y, Liu T, Chen K, Chen T, Fu H.   +7 more
europepmc   +1 more source

Controlled Delivery and Light-Induced Release of Magic Spot Nucleotides in Escherichia coli

Popp C, Moser P, Liu X, Freitag J, Prucker I, Zscherp R, Wang X, Klahn P, Koch H, Bange G, Jessen HJ.   +10 more
europepmc   +1 more source

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Acid-Cleavable Guanosine Triphosphate-Photoaffinity Probe for Global Profiling of Guanosine Triphosphate-Binding Proteins and Their Active Sites

Analytical Chemistry
Guanosine triphosphate (GTP)-binding proteins function as molecular switches in cell signaling, playing critical roles in various biological pathways. Their dysregulation is associated with the causes and progression of many diseases. Systematic analysis of GTP-binding proteins would facilitate studies of related signaling pathways and drugs ...
Can Gao, Mengxuan Li, Jing Tan, Zhiming Wang, Jing Xu, Wenwen Li, Feng Shi, Zhenzhen Chen, Rong Cai   +8 more
openaire   +3 more sources

Guanosine triphosphate cyclohydrolase 1 promoter deletion causes dopa‐responsive dystonia

Movement Disorders, 2012
AbstractBackground:Autosomal dominant dopa‐responsive dystonia (AD‐DRD) is caused by a biochemical defect primarily resulting from guanosine triphosphate cyclohydrolase 1 gene (GCH1) mutations. Few families have been reported without mutations in GCH1.Methods:Genome‐wide linkage analysis and positional cloning to identify the genetic defect in a ...
Theuns, Jessie, Crosiers, David, Debaene, Luc, Nuytemans, Karen, Meeus, Bram, Sleegers, Kristel, Goossens, Dirk, Corsmit, Ellen, Elinck, Ellen, Peeters, Karin, Mattheijssens, Maria, Pickut, Barbara, Del-Favero, Jurgen, Engelborghs, Sebastiaan, De Deyn, Peter Paul, Cras, Patrick, Van Broeckhoven, Christine   +16 more
openaire   +5 more sources

Autosomal dominant guanosine triphosphate cyclohydrolase I deficiency (Segawa disease)

Annals of Neurology, 2003
Autosomal dominant guanosine triphosphate cyclohydrolase I (GCH-I) deficiency (Segawa disease) is a dopa-responsive dystonia caused by mutation of the GCH-I gene located on 14q22.1-q22.2. Neurohistochemical examination revealed a decrease of the tyrosine hydroxylase protein as well as its activity in the striatum and decrease of dopamine content ...
Masaya, Segawa, Yoshiko, Nomura, Nobuyoshi, Nishiyama   +2 more
openaire   +3 more sources

Aberrant guanosine triphosphate–beta‐tubulin interaction in Alzheimer's disease

Annals of Neurology, 1989
AbstractGuanosine triphosphate (GTP) is an absolute requirement for tubulin polymerization in situ. The nucleotide photoaffinity probe 8‐azidoguanosine 5′‐triphosphate (8N3GTP) has been shown to be a biological mimic of GRP in this system and, also, an effective active site probe of the exchangeable GRP binding site.
S, Khatoon, S R, Campbell, B E, Haley, J T, Slevin   +3 more
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Chemosensing of Guanosine Triphosphate Based on a Fluorescent Dinuclear Zn(II)-Dipicolylamine Complex in Water.

Inorganic Chemistry, 2020
Guanosine triphosphate (GTP) is a key biomarker of multiple cellular processes and human diseases. The new fluorescent dinuclear complex [Zn2(L)(S)][OTf]4, 1 (asymmetric ligand, L = 5,8-Bis{[bis(2-pyridylmethyl)amino] methyl}quinoline, S = solvent, and ...
Iván J. Bazany‐Rodríguez, María K Salomón-Flores, Joanatan M. Bautista-Renedo, N. González-Rivas, A. Dorazco‐González   +4 more
semanticscholar   +1 more source

Diversity of mechanisms in Ras-GAP catalysis of guanosine triphosphate hydrolysis revealed by molecular modeling.

Organic and biomolecular chemistry, 2019
The mechanism of the deceptively simple reaction of guanosine triphosphate (GTP) hydrolysis catalyzed by the cellular protein Ras in complex with the activating protein GAP is an important issue because of the significance of this reaction in cancer ...
B. Grigorenko, E. Kots, A. Nemukhin
semanticscholar   +1 more source