Results 211 to 220 of about 159,662 (351)

Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides.

, 1976
Chhabirani Mukherjee, Robert J. Lefkowitz   +1 more
openalex   +1 more source

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

Advanced Science, Volume 12, Issue 17, May 8, 2025.
STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde   +3 more
wiley   +1 more source

Preparation of Homogeneous Elongation Factor G and Examination of the Mechanism of Guanosine Triphosphate Hydrolysis

, 1974
Michael S. Rohrbach, Mary E. Dempsey, James W. Bodley   +2 more
openalex   +1 more source

Inositol 1,4,5‐trisphosphate‐ and guanosine 5′‐O‐(3‐thio triphosphate)‐induced Ca²⁺ release in cultured airway smooth muscle [PDF]

, 1991
Lorna C. Chopra, C.H.C. Twort, I. R. Cameron, Jeremy Ward   +3 more
openalex   +1 more source

Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS‐AD‐linked degenerative phenotypes in the Dp16 mouse model of Down syndrome

Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract INTRODUCTION Down syndrome (DS) markedly raises the risk of Alzheimer's disease (DS‐AD). Our findings identified widespread dysregulation of the endolysosomal network (ELN) in DS and DS‐AD brains, driven by increased APP gene dose, hyperactivation of RAB5, and elevated levels of guanine nucleotide exchange factors (GEFs) for RABs 7 and 11 ...
Xu‐Qiao Chen, Xinxin Zuo, Ann Becker, Michael Mante, Jazmin B. Florio, Satish G. Jadhav, Ricardo Albay, Aaron Johnstone, Dmitry Karachentsev, Robert Rissman, Hien Zhao, Steven F. Dowdy, William C. Mobley   +12 more
wiley   +1 more source

Dexras1/AGS-1, a Steroid Hormone-Induced Guanosine Triphosphate-Binding Protein, Inhibits 3′,5′-Cyclic Adenosine Monophosphate-Stimulated Secretion in AtT-20 Corticotroph Cells¹ [PDF]

, 2001
Timothy E. Graham, T. Alexander Key, Kathleen A. Kilpatrick, Richard I. Dorin   +3 more
openalex   +2 more sources

Initiation Factor 2-Dependent Ribosomal Binding of N -Formylmethionyl-Transfer RNA Without Added Guanosine Triphosphate

, 1972
Rajarshi Mazumder
openalex   +1 more source

An insulin receptor peptide (1135-1156) stimulates guanosine 5′-[γ-thio]triphosphate binding to the 67 kDa G-protein associated with the insulin receptor [PDF]

, 1993
Hanjoong Jo, Wilson Radding, G.M. Anantharamaiah, Jay M. McDonald   +3 more
openalex   +1 more source

Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose

Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract INTRODUCTION Down syndrome (DS) markedly increases the risk of Alzheimer's disease (DS‐AD), but the role of RAB5 hyperactivation in its pathogenesis remains unclear. METHODS Postmortem brain samples from individuals with DS, with and without AD, and a partial trisomy 21 case with only two amyloid precursor protein (APP) gene copies, were ...
Xu‐Qiao Chen, Xinxin Zuo, Ann Becker, William C. Mobley   +3 more
wiley   +1 more source

Effects of insulin and guanosine 5′-[γ-thio]triphosphate on fatty acid synthesis and lipolysis within electropermeabilized fat-cells [PDF]

, 1992
Guy A. Rutter, Richard M. Denton
openalex   +1 more source