Results 291 to 300 of about 162,062 (330)

Neurologic and psychiatric manifestations in a family with a mutation in exon 2 of the guanosine triphosphate-cyclohydrolase gene.

Archives of Neurology, 2001
OBJECTIVE To investigate the range of clinical features to correlate genotypic and phenotypic manifestations in hereditary progressive and/or levodopa-responsive dystonia due to a defect in the guanosine triphosphate-cyclohydrolase (GCH1) gene.
H. Hahn, M. Trant, M. Brownstein, R. Harper, S. Milstien, I. Butler   +5 more
semanticscholar   +1 more source

Preparative method of obtaining guanosine 5′-triphosphate

Chemistry of Natural Compounds, 1965
1. The kinetics of the formation of guanosine 5′-triphosphate, 5′-diphosphate, and 5′-monophosphate in the reaction of the morpholide of guanosine 5′-monophosphate with bis-(tributylammonium) pyrophosphate in pyridine at 27° has been recorded. 2. In the reaction of the morpholide of guanosine 5′-monophosphate with bis-(tributylammonium) pyrophosphate ...
T. S. Lomakina, N. I. Grineva
openaire   +2 more sources

Deactivation of visual transduction without guanosine triphosphate hydrolysis by G protein.

Science, 1992
G proteins couple receptors to their target enzymes in many signal transduction cascades. It has generally been thought that deactivation of such cascades cannot occur without the hydrolysis of guanosine triphosphate (GTP) by G protein.
M. A. Erickson, P. Robinson, J. Lisman
semanticscholar   +1 more source

Evidence for Guanosine Triphosphate—Binding Proteins in Trypanosoma cruzi

The American Journal of Tropical Medicine and Hygiene, 1994
The transformation of the parasite Trypanosoma cruzi from the blood-borne trypomastigote to the intracellular amastigote constitutes a key clinical feature in the pathophysiology of Chagas' disease. That this transition occurs without change in the integrity of the plasma membrane of the parasite suggests the presence of biochemical structures, i.e ...
Huan Huang, Oz Hs, Stephen A. Morris, M Wittner, H. B. Tanowitz, John P. Bilezikian   +5 more
openaire   +3 more sources

Guanosine triphosphate activation of brain adenylate cyclase: enhancement by long-term antidepressant treatment.

Science, 1983
Activation of adenylate cyclase by a stable guanosine 5'-triphosphate analog was augmented in brain membrane preparations from rats treated on a long-term basis with tricyclic antidepressants or electroconvulsive shock.
D. Menkes, M. Rasenick, M. Wheeler, M. Bitensky   +3 more
semanticscholar   +1 more source

The effect of guanosine 5′-triphosphate analogues on protein synthesis

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract Four GTP analogues, 6-mercaptoguanosine 5′-triphosphate (I), N2-methylguanosine 5′-triphosphate (II), N2-dimethylguanosine 5′-triphosphate (III) and 8-bromoguanosine 5′-triphosphate, (IV) were synthesized chemically and tested for their ability to replace GTP in the cell-free amino acid incorporation system of Escherichia coli.
Morio Ikehara, Eiko Ohtsuka, Hitoshi Uno, Shintaro Oyabu   +3 more
openaire   +3 more sources

Direct incorporation of guanosine 5-diphosphate into microtubules without guanosine 5'-triphosphate hydrolysis

Biochemistry, 1986
Using highly purified calf brain tubulin bearing [8-14C]guanosine 5'-diphosphate (GDP) in the exchangeable nucleotide site and heat-treated microtubule-associated proteins (both components containing negligible amounts of nucleoside diphosphate kinase and nonspecific phosphatase activities), we have found that a significant proportion of exchangeable ...
Janendra K. Batra, Chii M. Lin, Ernest Hamel   +2 more
openaire   +3 more sources

Adenosine Triphosphate and Guanosine Triphosphate Determinations in Intertidal Sediments

1979
Measurements were made of the spatial distributions of adenosine triphosphate (ATP) on a variety of sandy beaches. Samples were collected during ebb flow and extracted in the field using cold sulfuric acid and ethylenediamine tetraacetate (EDTA); the neutralized extracts were immediately frozen for subsequent analyses.
openaire   +2 more sources

Excitation of Limulus photoreceptors by vanadate and by a hydrolysis-resistant analog of guanosine triphosphate.

Science, 1981
Discrete voltage fluctuations that occur spontaneously or in response to dim lights can be recorded from the ventral photoreceptors of Limulus. The injection of vanadate or the hydrolysis-resistant analog of guanosine triphosphate, GTP-gamma-S, into ...
A. Fein, D. Corson
semanticscholar   +1 more source

Structural and Functional Relationships of Guanosine Triphosphate Binding Proteins

1988
Information available at present documents the existence of three well-defined classes of guanine nucleotide binding proteins functioning as signal transducers: Gs and Gi which stimulate and inhibit adenylate cyclase, respectively, and transducin which transmits and amplifies the signal from light-activated rhodopsin to cGMP-dependent phosphodiesterase
Ernst J.M. Helmreich, Thomas Pfeuffer
openaire   +3 more sources