Results 291 to 300 of about 159,662 (351)

Aberrant guanosine triphosphate–beta‐tubulin interaction in Alzheimer's disease

Annals of Neurology, 1989
AbstractGuanosine triphosphate (GTP) is an absolute requirement for tubulin polymerization in situ. The nucleotide photoaffinity probe 8‐azidoguanosine 5′‐triphosphate (8N3GTP) has been shown to be a biological mimic of GRP in this system and, also, an effective active site probe of the exchangeable GRP binding site.
John T. Slevin, Boyd E. Haley, Susan R. Campbell, Sabiha Khatoon   +3 more
openaire   +4 more sources

Chemosensing of Guanosine Triphosphate Based on a Fluorescent Dinuclear Zn(II)-Dipicolylamine Complex in Water.

Inorganic Chemistry, 2020
Guanosine triphosphate (GTP) is a key biomarker of multiple cellular processes and human diseases. The new fluorescent dinuclear complex [Zn2(L)(S)][OTf]4, 1 (asymmetric ligand, L = 5,8-Bis{[bis(2-pyridylmethyl)amino] methyl}quinoline, S = solvent, and ...
Iván J. Bazany‐Rodríguez, María K Salomón-Flores, Joanatan M. Bautista-Renedo, N. González-Rivas, A. Dorazco‐González   +4 more
semanticscholar   +1 more source

Interactions of tubulin with vinblastine and guanosine triphosphate

Journal of Molecular Biology, 1972
Abstract Tubulin isolated from calf brain contains one mole of tightly bound nucleotide per 120,000 g of protein, chiefly as GDP. Another mole of GTP can be bound in exchange with the medium. Transphosphorylation occurs between the terminal phosphate of the exchangeable nucleotide and the tightly bound GDP.
Robert W. Berry, Robert W. Berry, Michael L. Shelanski, Michael L. Shelanski   +3 more
openaire   +3 more sources

Preparative Enzymatic Conversion of Guanosine-5′ -monophosphate to Guanosine-5′ - triphosphate [PDF]

Synlett, 1990
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Regine Stiller, Joachim Thiem
openaire   +2 more sources

Luminescent vesicular nanointerface: a highly selective and sensitive "turn-on" sensor for guanosine triphosphate.

ACS Applied Materials and Interfaces, 2014
A novel amphiphilic Tb(3+) complex (TbL(3+)(I)) consisting of a +3 charged head and a hydrophobic alkyl chain has been developed. It spontaneously self-assembles in water and forms stable vesicles at neutral pH.
Hairui Lei, Jing Liu, Junlin Yan, Shih-Fu Lu, Yu Fang   +4 more
semanticscholar   +1 more source

Beneficial prenatal levodopa therapy in autosomal recessive guanosine triphosphate cyclohydrolase 1 deficiency.

Archives of Neurology, 2012
OBJECTIVE To report the first prenatal dopaminergic replacement therapy in autosomal recessive (AR) guanosine triphosphate cyclohydrolase 1 (GTPCH) deficiency without hyperphenylalaninemia. DESIGN Case reports, literature review, and video presentation.
N. Brüggemann, J. Spiegler, Y. Hellenbroich, T. Opladen, S. Schneider, U. Stephani, R. Boor, G. Gillessen‐Kaesbach, J. Sperner, C. Klein   +9 more
semanticscholar   +1 more source

Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives.

Organic and biomolecular chemistry, 2012
We report that a polyhedral oligomeric silsesquioxane (POSS) core in a dendrimer can enhance the affinity of the molecular recognition via hydrogen bonds between 1,8-naphthyridine and guanosine nucleotides.
Kazuo Tanaka, M. Murakami, Jonghwan Jeon, Y. Chujo   +3 more
semanticscholar   +1 more source

A ratiometric fluorescence recognition of guanosine triphosphate on the basis of Zn(II) complex of 1,4-bis(imidazol-1-ylmethyl) benzene.

In Analysis, 2012
As one vital member among the family of phosphates, guanosine triphosphate (GTP) not only plays a very important role in many critical biological processes but also closely associates with definite pathological states.
L. Liang, S. Zhen, X. Zhao, C. Huang
semanticscholar   +1 more source

Acid-Cleavable Guanosine Triphosphate-Photoaffinity Probe for Global Profiling of Guanosine Triphosphate-Binding Proteins and Their Active Sites.

Analytical Chemistry
Guanosine triphosphate (GTP)-binding proteins function as molecular switches in cell signaling, playing critical roles in various biological pathways. Their dysregulation is associated with the causes and progression of many diseases. Systematic analysis
Can Gao, Mengxuan Li, Jing Tan, Zhiming Wang, Jing Xu, Wenwen Li, Feng Shi, Zhenzhen Chen, Rong Cai   +8 more
semanticscholar   +1 more source