Results 81 to 90 of about 621,235 (315)
“Ne bis in idem” Principle, Double Jeopardy Guarantee and Their Application in the Fields of Punishment and Sanctioning: Differences, Merits and Demerits [PDF]
Societas et Iurisprudentia, 2017 The authors of the presented paper analyse the case law of the European Court of Human Rights in the field of the “ne bis in idem” guarantee. They focus in particular on the approach of this court to the issue of liability for crimes and payment offenses.
Ľubica Masárová, Michal Maslen
doaj
Participatory Management and Good Governance [PDF]
Robotica & Management, 2020 Good governance contains a set of rules with a political, economic, legal and social basis that coordinate the organization and functioning of the activity of the state executive system.
Claudia Pau, Jeanina Ciurea
doaj
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Credit guarantee schemes supporting small enterprise development: A review
, 2012 Access to finance has become increasingly difficult, particularly for new and service-based industries without tangible assets to use as security. Globally, credit guarantee schemes (CGS) are seen as important instruments to facilitate achievement of ...
Reutemann, Jody +2 more
core
El paradigma del derecho en Colombia: la constitucionalización del derecho penal
Nuevo Derecho, 2019 El texto propone un análisis de las categorías de paradigmas del derecho que Ferrajoli en sus obras propone, para entender históricamente cómo el derecho se ha desarrollado y cuáles son las implicaciones que conllevan los cambios a través del tiempo en ...
Ivanna Calvete León +1 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Tracking error with minimum guarantee constraints [PDF]
In recent years the popularity of indexing has greatly increased in financial markets and many different families of products have been introduced. Often these products also have a minimum guarantee in the form of a minimum rate of return at specified ...
Elio Canestrelli, Diana Barro
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source