Results 91 to 100 of about 3,940,943 (324)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Guaranteed Wages, Company Unemployment Benefits and the New Unemployment Insurance Act [PDF]
Relations industrielles, 2014 The purpose of this article is to continue the study of the factors involved in the possible co-ordination of unemployment insurance with the varied schemes entitled, "Guaranteed Wages", to amplify some of the issues that have been already raised, and to base the analysis on the new Unemployment Insurance Act, which came into operation in October, 1955.
openaire +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Jurnal Media Hukum, 2016 The development of telecommunications business major effect on development. However, this requires a relatively large funds , so that the telecommunications service provider is in need of funds from the bank to the credit agreement .
Siti Malikhatun Badriyah
doaj
Economic Implications of ERISA [PDF]
If the intent of the Employee Retirement Income Security Act, ERISA, was to assure that beneficiaries of insolvent pension plans receive adequate pension benefits, sharp increases in nominal rates of interest have blunted that purpose.
Jeremy I. Bulow +2 more
core
Tindak Ujar Komisif Dalam Novel Herzog Karya Saul Bellow (Suatu Analisis Pragmatik) [PDF]
, 2015 This reseach entitled Commisive Act in the novel Herzog by Saul Bellow. In pragmatic field, communication is a fission of problem. Leech (1983) devide the speech situation into five aspects one of them is speech act.
PUA, G. A. (GABRIELA)
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Deconstructing the healthcare guarantee
Offentlig Förvaltning: Scandinavian Journal of Public Administration, 2012 <p>According to the Swedish Health and Medical Service Act, healthcare is to be provided to the population according to need, on equal terms, and be accessible, a part of healthcare that has been criticized. With the aim of improving accessibility,
Lars Nordgren
doaj
, 2019 In this new book we return to the challenge of deepening the task to the point of imagining the university formed by commoner university students. It is a turn, a new place from which to name and reconsider community management and action from a sense of
Altamirano Chingay, Karla +10 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source