Results 131 to 140 of about 102,937 (395)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Examining the Hadith of “Al-sultan wliyo man la wliya lah” [PDF]

open access: yesآموزه‌‌های فقه مدني, 2009
T the hadith of “Al-sultan wliyo man la wliya lah” is regarded as a reason in the discussion of the guardianship of Islamic jurisprudence. This hadith has been considered from the viewpoints of its chain and denotation.
Seyyed Jafar Alavi Gonabadi
doaj  

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

CHILDREN'S ORPHANHOOD IN THE PEASANTRY IN THE FIRST HALF OF THE 19TH CENTURY (BASED ON MATERIALS OF VITEBSK AND MINSK PROVINCES)

open access: yesВестник Брянского государственного университета
The article is an attempt to study such a social phenomenon as child orphanhood among the peasantry in the first half of the 19th century in the Russian Empire using the example of Vitebsk and Minsk provinces. The sources were both a number of government
Pyshkalo K.G.
doaj   +1 more source

Antibiotic Guardianship [PDF]

open access: yesJournal of Infection Prevention, 2014
openaire   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Incorporating indigenous values in corporate social responsibility reports [PDF]

open access: yes, 2012
Purpose– The purpose of this paper is to show how a major state-owned enterprise in New Zealand uses its annual report to promote the image of an organisation concerned with the local community including Māori, the indigenous people of New Zealand, Māori
Pitu, Elizabeth   +2 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Getting through the Door: Threshold Procedural Considerations in Right-to-Die Litigation [PDF]

open access: yes, 1995
Ms. DiPaolo explains how judges may use mootness, ripeness and standing to avoid getting involved in right-to-die cases.
DiPaolo, Sharon F.
core   +1 more source

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