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Therapeutic targeting in breast cancer for the treatment of lymph node metastasis: GUCY1A3.

Metastasis is the major cause of death from cancer.  Metastasis to the lymph node (“regional” metastasis) generally precedes distant metastasis, and we recently demonstrated that metastasis to the lymph nodes is a likely prerequisite for metastasis to the central nervous system (CNS) in humans with breast cancer (1-8).
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Loss of Gucy1a3 causes poor post-stroke recovery by reducing angiogenesis via the HIF-1α/VEGFA signaling pathway in mice

open access: closed, 2023
Man Luo   +10 more
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Abstract 13110: Digenic Mutations in GUCY1A3 and CCT7 Increases Risk of Myocardial Infarction in an Extended Family

open access: closed, 2012
P. Rumpf   +14 more
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Abstract 14847: Genetic Variation at the Coronary Artery Disease Risk Locus GUCY1A3 Modifies Cardiovascular Disease Prevention Effects of Aspirin

open access: closed, 2018
Kathryn T. Hall   +8 more
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