Results 21 to 30 of about 1,810 (157)

Soluble Guanylate Cyclase α1–Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma [PDF]

, 2013
Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown.
Abernathy, Emma, Alt, Clemens, Arora, Pankaj, Bloch, Kenneth Daniel, Brouckaert, Peter, Buys, Emmanuel, Clerté, Maeva, de Waard, Nadine, Giani, Andrea, Gong, Haiyan, Gregory, Meredith S., Hayton, Sarah R., Jones, Alexander, Kang, Jae Hee Hee, Ko, Yu-Chieh, Ksander, Bruce R., Lin, Charles P., Loomis, Stephanie J., Malhotra, Rajeev, Nathan, Daniel, Oh, Dong-Jin, Pasquale, Louis, Ren, Ruiyi, Rhee, Douglas J, Scherrer-Crosbie, Marielle, Tainsh, Laurel T., Tainsh, Robert Edward Tillinghast, Turcotte, Raphael, Wiggs, Janey Lee, Yu, Binglan   +29 more
core   +13 more sources

Estudios genéticos en pacientes y familias con sospecha de enfermedades neurovasculares hereditarias

Kranion, 2023
Introducción: Las enfermedades neurovasculares minoritarias como CADASIL, cavernomatosis múltiple familiar o arteriopatía de moyamoya requieren un abordaje diagnóstico multidisciplinario que incluya un panel genético.
Sara Banda, Paloma Menéndez-Valladares, Elena Muiño, Elena Arce, Ana Domínguez-Mayoral, Flora Sánchez, Juan M.ª Borreguero, Enrique Montero, Pablo Duque, Soledad Pérez-Sánchez, Irene Alonso, Dominique Hervé, Sonia Reyes, Jabouley Aude, Carla Machado, Hugues Chabriat, Juan J. Ríos, Marina Alonso-Riaño, Ana Trujillo, Manoelle Kossorotoff, Elisabeth Tournier-Lasserve, Joan Montaner   +21 more
doaj   +1 more source

sGC Activity and Regulation of Blood Flow in a Zebrafish Model System

Frontiers in Physiology, 2021
Soluble guanylyl cyclase (sGC) protein is a heterodimer formed by two subunits encoded by GUCY1A1 and GUCY1B1 genes. The chromosomal locus 4q32.1 harbors both of these genes, which has been previously significantly associated with coronary artery disease,
Krishan K. Vishnolia, Krishan K. Vishnolia, Krishan K. Vishnolia, Aleksandar Rakovic, Celine Hoene, Celine Hoene, Celine Hoene, Karim Tarhbalouti, Karim Tarhbalouti, Karim Tarhbalouti, Zouhair Aherrahrou, Zouhair Aherrahrou, Zouhair Aherrahrou, Jeanette Erdmann, Jeanette Erdmann, Jeanette Erdmann   +15 more
doaj   +1 more source

Role of epigenetic modifications and aging in inflammatory bowel disease

MedComm – Future Medicine, Volume 2, Issue 4, December 2023., 2023
In this perspective, we provide a summary of previous studies focusing on the intersection of epigenetic modifications, diet metabolism, and aging in inflammatory bowel disease (IBD). We explore the connection between relevant alterations in epigenetic modifications associated with aging and diet metabolism with the inflammatory response and microbial ...
Yanting Du, Guo Li, Yang Zhou, Min Zuo, Hu Wang, Yanan Liu, Liquan Hong   +6 more
wiley   +1 more source

Whole exome sequencing identifies MRVI1 as a susceptibility gene for moyamoya syndrome in neurofibromatosis type 1. [PDF]

PLoS ONE, 2018
BACKGROUND AND PURPOSE:Moyamoya angiopathy is a progressive cerebral vasculopathy. The p.R4810K substitution in RNF213 has previously been linked to moyamoya disease in Asian populations.
Claudia Santoro, Teresa Giugliano, Markus Kraemer, Annalaura Torella, Jan Claudius Schwitalla, Mario Cirillo, Daniela Melis, Peter Berlit, Vincenzo Nigro, Silverio Perrotta, Giulio Piluso   +10 more
doaj   +1 more source

Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice

British Journal of Pharmacology, Volume 180, Issue 18, Page 2361-2376, September 2023., 2023
Background and purpose Alcohol abuse has been associated with erectile dysfunction (ED), but the implicated molecular mechanisms are unresolved. This study analyses the role of alterations in soluble guanylyl cyclase (sGC) in ED. Experimental approach ED was analysed in adult male C57BL/6J mice subjected to the Chronic Intermittent Ethanol (CIE ...
Miguel A. Olivencia, Leticia Gil de Biedma‐Elduayen, Pablo Giménez‐Gómez, Bianca Barreira, Argentina Fernández, Javier Angulo, Maria Isabel Colado, Esther O'Shea, Francisco Perez‐Vizcaino   +8 more
wiley   +1 more source

PRDM16 expression and function in mammalian cochlear development

Developmental Dynamics, Volume 251, Issue 10, Page 1666-1683, October 2022., 2022
Abstract Background PR domain containing 16 (PRDM16) is a key transcriptional regulator in the development of craniofacial, adipose, and neural tissues. Our lab identified PRDM16 expression in the epithelial cells of the Kölliker's organ (KO) that starts at ~E13.5 and is maintained until KO disappearance.
Michael Ebeid, Kathy Barnas, Hongji Zhang, Amal Yaghmour, Gabriele Noreikaite, Bryan C. Bjork   +5 more
wiley   +1 more source

Risk and Protective Factors of Lifetime Cocaine-Associated Chest Pain

Frontiers in Psychiatry, 2021
Introduction: Cocaine users often present with repetitive events of cocaine-associated chest pain (CACP), clinically resembling acute coronary syndromes.
Virgile Clergue-Duval, Virgile Clergue-Duval, Virgile Clergue-Duval, Virgile Clergue-Duval, Louise Nicolas-Sacy, Emily Karsinti, Emily Karsinti, Emily Karsinti, Emily Karsinti, El-Hadi Zerdazi, El-Hadi Zerdazi, Jean-Louis Laplanche, Jean-Louis Laplanche, Jean-Louis Laplanche, Georges Brousse, Andries T. Marees, Eske M. Derks, Patrick Henry, Patrick Henry, Frank Bellivier, Frank Bellivier, Frank Bellivier, Frank Bellivier, Florence Vorspan, Florence Vorspan, Florence Vorspan, Florence Vorspan, Vanessa Bloch, Vanessa Bloch, Vanessa Bloch, Vanessa Bloch   +30 more
doaj   +1 more source

Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions. [PDF]

, 2020
Progestins are widely used for the treatment of gynecologic disorders and alone, or combined with an estrogen, are used as contraceptives. While their potencies, efficacies and side effects vary due to differences in structures, doses and routes of ...
Balayan, Shayna, Chen, Joseph C, Giudice, Linda C, Greenblatt, Ruth M, Houshdaran, Sahar, Irwin, Juan C, Smith-McCune, Karen, Vallvé-Juanico, Júlia, Vo, Kim Chi   +8 more
core   +2 more sources

Identification of Key Genes and Pathways in Osteosarcoma by Bioinformatics Analysis

Computational and Mathematical Methods in Medicine, Volume 2022, Issue 1, 2022., 2022
Purpose. Osteosarcoma (OS) is the most primary bone malignant tumor in adolescents. Although the treatment of OS has made great progress, patients’ prognosis remains poor due to tumor invasion and metastasis. Materials and Methods. We downloaded the expression profile GSE12865 from the Gene Expression Omnibus database.
Xiujin Chen, Nan Zhang, Yuanyuan Zheng, Zhichao Tong, Tuanmin Yang, Xin Kang, Yan He, Liang Dong, Jianxin Shi   +8 more
wiley   +1 more source