Results 31 to 40 of about 1,810 (157)

Genetics of coronary artery disease in the post‐GWAS era

Journal of Internal Medicine, Volume 290, Issue 5, Page 980-992, November 2021., 2021
Abstract During the past decade, genome‐wide association studies (GWAS) have transformed our understanding of many heritable traits. Three recent large‐scale GWAS meta‐analyses now further markedly expand the knowledge on coronary artery disease (CAD) genetics in doubling the number of loci with genome‐wide significant signals.
Zhifen Chen, Heribert Schunkert
wiley   +1 more source

Identification ACTA2 and KDR as key proteins for prognosis of PD‐1/PD‐L1 blockade therapy in melanoma

Animal Models and Experimental Medicine, Volume 4, Issue 2, Page 138-150, June 2021., 2021
Abstract Programmed cell death protein 1 (PD‐1) /programmed cell death ligand 1 (PD‐L1) blockade is an important therapeutic strategy for melanoma, despite its low clinical response. It is important to identify genes and pathways that may reflect the clinical outcomes of this therapy in patients.
Yuchen Wang, Zhaojun Li, Zhihui Zhang, Xiaoguang Chen   +3 more
wiley   +1 more source

Discoveries of the specific expression of lncRNAs and mRNAs in hippocampus of rats after traumatic brain injury

Ibrain, Volume 7, Issue 2, Page 95-107, June 2021., 2021
Objects Explore the relationship between the neural function deficit and the changes of lncRNA and mRNA in hippocampus after traumatic brain injury (TBI) in rats. Methods Twenty male rats weighted 200‐240 grams were randomly divided into sham group and TBI group. Neurologic severity score (NSS) was performed after operation, and the hippocampus of rats
Juan Li, Yuan‐Tao Pan, Jun‐Jie Chen, Yi Wang, Hong‐Su Zhou, Xue‐Yan Huang, Shi‐Xia Liao   +6 more
wiley   +1 more source

Modulation of vascular contraction via soluble guanylate cyclase signaling in a novel ex vivo method using rat precision‐cut liver slices

Pharmacology Research &Perspectives, Volume 9, Issue 3, June 2021., 2021
Cultures of rat precision cut liver slices (PCLS) were used for ex vivo blood vessel function analysis via live recording. The sGC activator BI703704 differentiates from the sGC stimulator Riociguat in the prevention of serotonin induced blood vessel contraction of normal and fibrotic rat liver slices.
Anouk Oldenburger, Gerald Birk, Marco Schlepütz, Andre Broermann, Birgit Stierstorfer, Steven S. Pullen, Jörg F. Rippmann   +6 more
wiley   +1 more source

Peptide‐based therapeutic cancer vaccine: Current trends in clinical application

Cell Proliferation, Volume 54, Issue 5, May 2021., 2021
Despite few clinical successes, peptide‐based therapeutic cancer vaccines have raised hopes in recent years. Therefore, better understanding of immune response, clinical benefits and adverse events, the formulations, and the promising combination strategies with conventional therapies foster development of the next generation of peptide‐based cancer ...
Wensi Liu, Haichao Tang, Luanfeng Li, Xiangyi Wang, Zhaojin Yu, Jianping Li   +5 more
wiley   +1 more source

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke [PDF]

, 2014
Aims: Cerebral small vessel disease (SVD) causes a fifth of all strokes plus diffuse brain damage leading to cognitive decline, physical disabilities and dementia.
Bailey, Emma L., Crawford, Wendy, Dominiczak, Anna F., Graham, Delyth, McBride, Martin W., McClure, John D., Smith, Colin, Sudlow, Cathie L.M., Wardlaw, Joanna M.   +8 more
core   +2 more sources

Cutaneous manifestations in Moyamoya angiopathy: A review

European Journal of Neurology, Volume 28, Issue 5, Page 1784-1793, May 2021., 2021
Moyamoya angiopathy (MA) is a rare progressive cerebrovascular disease resulting in early‐onset strokes. It may be associated with other heritable or acquired conditions. Apart from the brain, other organ manifestations have also been described. Some skin manifestations have been reported, for example, café‐au‐lait spots, hypomelanosis of Ito, livedo ...
Fouad Mitri, Anna Bersano, Dominique Hervé, Markus Kraemer   +3 more
wiley   +1 more source

Soluble Guanylate Cyclase Generation of cGMP Regulates Migration of MGE Neurons [PDF]

, 2013
Here we have provided evidence that nitric oxide-cyclic GMP (NO-cGMP) signaling regulates neurite length and migration of immature neurons derived from the medial ganglionic eminence (MGE).
Buys, E. S., Enikolopov, G., Mandal, S., Rubenstein, J. L., Stanco, A.   +4 more
core   +1 more source

[Retracted] DNA Hypomethylation of DOCK1 Leading to High Expression Correlates with Neurologic Deterioration and Poor Function Outcomes after Spontaneous Intracerebral Hemorrhage

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Objective. Spontaneous intracerebral hemorrhage (ICH) is a blood clot arising in the brain parenchyma in the absence of trauma or surgery and accounts for 10% to 15% of all strokes, leading to higher rates of mortality and morbidity than either ischemic stroke or subarachnoid hemorrhage.
Yufeng Gao, Xiaojie Fu, Lie Yu, Di Zhang, Zhengfang Lu, Kefei Cui, Chang Liu, Jiang Man, Jianping Wang, Songwen Tan   +9 more
wiley   +1 more source

Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines [PDF]

, 2019
Soluble guanylyl cyclase (sGC) is a heterodimeric enzyme constituted by two subunits, α1 and β1. Previously we have shown that 17β-estradiol (E2) exerts opposite effects on these subunits by increasing α1 and decreasing both β1 expression and enzymatic ...
Bollani, Sabrina Natalia, Cabilla, Jimena Paula, Cordeiro, Georgina, Duvilanski, Beatriz Haydee, Pino, María Teresa Luján, Ricci, Analía Gabriela, Ronchetti, Sonia Alejandra   +6 more
core   +1 more source