Results 51 to 60 of about 1,810 (157)

Statistical confidence estimation for Hi-C data reveals regulatory chromatin contacts [PDF]

open access: yes, 2014
Our current understanding of how DNA is packed in the nucleus is most accurate at the fine scale of individual nucleosomes and at the large scale of chromosome territories.
Bailey, Timothy L.   +2 more
core   +1 more source

Variants in GUCY1A3 influencing coronary artery disease [PDF]

open access: yes, 2018
Genome-wide association studies identified the common lead single nucleotide polymorphism rs7692387 at the GUCY1A3 locus to be associated with coronary artery disease (CAD) and myocardial infarction (MI). Furthermore, coding GUCY1A3 variants were found to be enriched in CAD/MI patients as compared to controls.
openaire   +1 more source

Integrated analysis of 34 microarray datasets reveals CBX3 as a diagnostic and prognostic biomarker in glioblastoma

open access: yesJournal of Translational Medicine, 2019
Background Glioblastomas have a high degree of malignancy, high recurrence rate, high mortality rate, and low cure rate. Searching for new markers of glioblastomas is of great significance for improving the diagnosis, prognosis and treatment of glioma ...
Siqi Wang   +9 more
doaj   +1 more source

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. [PDF]

open access: yes, 2011
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure).
Abecasis GR   +840 more
core   +8 more sources

Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption [PDF]

open access: yes, 2013
The objectives of this study were to determine innate differences in gene expression in 2 regions of the extended amygdala between 5 different pairs of lines of male rats selectively bred for high or low ethanol consumption: a) alcohol-preferring (P) vs.
Bell, Richard L.   +9 more
core   +2 more sources

Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. [PDF]

open access: yes, 2017
The complexity of the traumatic brain injury (TBI) pathology, particularly concussive injury, is a serious obstacle for diagnosis, treatment, and long-term prognosis. Here we utilize modern systems biology in a rodent model of concussive injury to gain a
Agrawal, Rahul   +5 more
core   +2 more sources

Gene expression profile and signaling pathways in MCF-7 breast cancer cells mediated by acyl-CoA synthetase 4 overexpression [PDF]

open access: yes, 2015
Aim: Breast cancer comprises a heterogeneous group of diseases that vary in morphology, biology, behavior and response to therapy. Previous studies have identified an acyl-CoA synthetase 4 (ACSL4) gene-expression pattern correlated with very aggressive ...
Castillo, Ana Fernanda   +5 more
core   +1 more source

Identification of Anoikis‐Related Genes in Gastric Cancer: Bioinformatics and Experimental Validation

open access: yesCancer Medicine, Volume 14, Issue 8, April 2025.
ABSTRACT Introduction Distant metastasis is the main reason for the poor prognosis of gastric cancer, and anoikis refers to the cell death caused when cells detach from the extracellular matrix or adhere in incorrect locations, playing an important role in the distant metastasis of gastric cancer.
Chao Song   +9 more
wiley   +1 more source

Gentrepid V2.0: a web server for candidate disease gene prediction [PDF]

open access: yes, 2013
Contains fulltext : 124935.pdf (publisher's version ) (Open Access)BACKGROUND: Candidate disease gene prediction is a rapidly developing area of bioinformatics research with the potential to deliver great benefits to human health.
Bains, Naresh   +8 more
core   +2 more sources

Comprehensive analysis of an mRNA co-expression network and a ceRNA network reveals potential prognostic biomarkers in oral squamous cell carcinoma

open access: yesEgyptian Journal of Medical Human Genetics
Background Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive oral cancer with a poor prognosis. Its polygenic risk is likely influenced by complex transcriptional disorders involving networks of co-expressed and functionally related genes,
Liming He   +6 more
doaj   +1 more source

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