Results 61 to 70 of about 1,810 (157)

Social threat exposure in juvenile mice promotes cocaine-seeking by altering blood clotting and brain vasculature [PDF]

, 2016
Childhood maltreatment is associated with increased severity of substance use disorder and frequent relapse to drug use following abstinence. However, the molecular and neurobiological substrates that are engaged during early traumatic events and ...
Aricò, Eleonora, Bisicchia, Elisa, Carola, Valeria, Castiello, Luciano, D'Amato, Francesca R., Ermakova, Olga, LO IACONO, Luisa, Oddi, Diego, PUGLISI ALLEGRA, Stefano, Valzania, Alessandro, VISCO COMANDINI, Federica, Viscomi, Maria Teresa   +11 more
core   +1 more source

Hypertensive effect of downregulation of the opioid system in mouse model of different activity of the endogenous opioid system [PDF]

, 2021
The opioid system is well-known for its role in modulating nociception and addiction development. However, there are premises that the endogenous opioid system may also affect blood pressure. The main goal of the present study was to determine the impact
Gaciong, Zbigniew, Jaskuła, Kinga, Poznański, Piotr, Religa, Piotr, Sacharczuk, Mariusz, Siedliński, Mateusz, Skiba, Dominik, Szczepaniak, Piotr, Łazarczyk, Marzena   +8 more
core   +2 more sources

Additional file 5 of Biallelic variants in NOS3 and GUCY1A3, the two major genes of the nitric oxide pathway, cause moyamoya cerebral angiopathy

, 2023
Additional file 5: Quantitative PCR results comparing relative expression of NOS3 mRNA in cells transfected with the wild type and with the M035 mutated cDNA.
Guey, Stéphanie, Hervé, Dominique, Kossorotoff, Manoëlle, Ha, Guillaume, Aloui, Chaker, Bergametti, Françoise, Arnould, Minh, Guenou, Hind, Hadjadj, Jessica, Dubois Teklali, Fanny, Riant, Florence, Balligand, Jean-Luc, Uzan, Georges, Villoutreix, Bruno O., Tournier-Lasserve, Elisabeth   +14 more
openaire   +1 more source

Does Adding Single‐Nucleotide Polymorphisms to Risk Algorithms Improve Cardiovascular Disease Risk Prediction in Rheumatoid Arthritis? An Internal and External Validation of a Clinical Risk Score

Arthritis Care &Research, Volume 76, Issue 10, Page 1419-1426, October 2024.
Objective Current risk algorithms do not accurately predict cardiovascular disease (CVD) risk in rheumatoid arthritis (RA). An area of interest is that of single‐nucleotide polymorphisms (SNPs), of which several have been associated with CVD in the general population.
Rabia Agca, Calin D. Popa, Martijn W. Heymans, Bart Crusius, Alexandre E. Voskuyl, Michael T. Nurmohamed   +5 more
wiley   +1 more source

Additional file 2 of Biallelic variants in NOS3 and GUCY1A3, the two major genes of the nitric oxide pathway, cause moyamoya cerebral angiopathy

, 2023
Additional file 2: 3D structural analysis of the functional consequences of the eNOS p.C648R variant and sGC alpha1 subunit p.R593H variant.
Guey, Stéphanie, Hervé, Dominique, Kossorotoff, Manoëlle, Ha, Guillaume, Aloui, Chaker, Bergametti, Françoise, Arnould, Minh, Guenou, Hind, Hadjadj, Jessica, Dubois Teklali, Fanny, Riant, Florence, Balligand, Jean-Luc, Uzan, Georges, Villoutreix, Bruno O., Tournier-Lasserve, Elisabeth   +14 more
openaire   +1 more source

The impact of phosphodiesterase‐5 inhibition or angiotensin‐converting enzyme inhibition on right and left ventricular remodeling in heart failure due to chronic volume overload

Pharmacology Research &Perspectives, Volume 12, Issue 1, February 2024.
Despite elevated cGMP levels in the lungs of sildenafil‐treated rats, PDE5i did not improve survival rate and did not change the cardiac and renal function of ACF rats with advanced HF. In contrast, mortality in the ACF model was reduced by ACEi treatment.
Tereza Tykvartova, Matus Miklovic, Martin Kotrc, Petra Skaroupkova, Ludmila Kazdova, Jaroslava Trnovska, Vojtech Skop, Michal Kolar, Jiri Novotny, Vojtech Melenovsky   +9 more
wiley   +1 more source

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma [PDF]

, 2014
Glaucoma is a progressive optic neuropathy characterized by visual field defects that ultimately lead to irreversible blindness (Alward, 2000; Anderson et al., 2006).
Buys, Emmanuel S., Ksander, Bruce R., Pasquale, Louis R., Potter, Lincoln R.   +3 more
core   +2 more sources

Additional file 4 of Biallelic variants in NOS3 and GUCY1A3, the two major genes of the nitric oxide pathway, cause moyamoya cerebral angiopathy

, 2023
Additional file 4: NOS3 homozygous splice variant in M084 and NOS3 homozygous missense variant in M035.
Guey, Stéphanie, Hervé, Dominique, Kossorotoff, Manoëlle, Ha, Guillaume, Aloui, Chaker, Bergametti, Françoise, Arnould, Minh, Guenou, Hind, Hadjadj, Jessica, Dubois Teklali, Fanny, Riant, Florence, Balligand, Jean-Luc, Uzan, Georges, Villoutreix, Bruno O., Tournier-Lasserve, Elisabeth   +14 more
openaire   +1 more source

Microarray Analysis of Visceral Adipose Tissue in Obese Women Reveals Common Crossroads Among Inflammation, Metabolism, Addictive Behaviors, and Cancer

Journal of Obesity, Volume 2024, Issue 1, 2024.
Background: Visceral adipose tissue (VAT) abnormalities are directly associated with obesity‐associated disorders. The underlying mechanisms that confer increased pathological risk to VAT in obesity have not been fully described. Methods: A case‐control study was conducted that included 10 women with obesity (36.80 ± 7.39 years, BMI ≥ 30 kg/m2) and 10 ...
Rolando Martínez-Romero, Susana Aideé González-Chávez, Victor Roberto Urías-Rubí, Víctor Manuel Gómez-Moreno, Manlio Favio Blanco-Cantero, Héctor Mario Bernal-Velázquez, Arturo Luévano-González, César Pacheco-Tena, Claire Stocker   +8 more
wiley   +1 more source

Additional file 3 of Biallelic variants in NOS3 and GUCY1A3, the two major genes of the nitric oxide pathway, cause moyamoya cerebral angiopathy

, 2023
Additional file 3: Candidate homozygous variants identified in the 6 consanguineous probands.
Guey, Stéphanie, Hervé, Dominique, Kossorotoff, Manoëlle, Ha, Guillaume, Aloui, Chaker, Bergametti, Françoise, Arnould, Minh, Guenou, Hind, Hadjadj, Jessica, Dubois Teklali, Fanny, Riant, Florence, Balligand, Jean-Luc, Uzan, Georges, Villoutreix, Bruno O., Tournier-Lasserve, Elisabeth   +14 more
openaire   +1 more source